CAJ | 학술논문

肝细胞癌(HCC)占原发性肝癌的90％以上.手术切除是治疗HCC的最佳治疗方案.但是,由于许多患者在诊断时已经处于晚期或存在多发病灶,所以只有少数患者能够施行手术.对于不能切除的肝细胞癌患者只有通过姑息性治疗来控制症状、提高生活质量、延长生存期.大量文献数据显示经导管肝动脉化疗栓塞术(transcatheter he-patic arterial chemoembolization,TACE)是非手术治疗的首选.传统的栓塞剂如碘油、明胶海绵等的应用虽然可延长患者的生存期,但由于这些栓塞剂存在易被清除、降解的局限性,从而影响栓塞效果.微球作为一种新型的栓塞剂,目前受到国内外研究者的广泛关注.根据微球的性质及作用将其分为两大类:单纯微球及载体微球.本研究就此两类微球做一综述.
간세포암(HCC)점원발성간암적90％이상.수술절제시치료HCC적최가치료방안.단시,유우허다환자재진단시이경처우만기혹존재다발병조,소이지유소수환자능구시행수술.대우불능절제적간세포암환자지유통과고식성치료래공제증상、제고생활질량、연장생존기.대량문헌수거현시경도관간동맥화료전새술(transcatheter he-patic arterial chemoembolization,TACE)시비수술치료적수선.전통적전새제여전유、명효해면등적응용수연가연장환자적생존기,단유우저사전새제존재역피청제、강해적국한성,종이영향전새효과.미구작위일충신형적전새제,목전수도국내외연구자적엄범관주.근거미구적성질급작용장기분위량대류:단순미구급재체미구.본연구취차량류미구주일종술.
Hepatocellular carcinoma (HCC) accounts for more than 90％ of primary liver cancer.Surgical resection is the standard modality of treatment.However,resection can only be performed in a minority of patients at the time of diagnosis.Data from several recently published studies are encouraging and suggest that TACE (transcatheter hepatic arterial chemoembolization) is superior to conservative treatment in patients with hepatocellular carcinoma who are not eligible for surgery.The traditional embolic agents such as iodized oil and gelatin sponge significantly prolonged survival in patients with HCC.However,the effects of these embolic agents are temporary.A new embolic agent,microspheres has attracted a lot of attention in our country and abroad.These microspheres can be divided into two categories:pure microspheres and carrier microspheres.In this paper,we review these two types of microspheres.