CAJ | 학술논문

目的探讨S期蛋白激酶相关蛋白(S-phase kinase-associated protein 2,Skp2)和p27蛋白在肺癌中表达及临床意义.方法应用免疫组织化学S-P法检测Skp2和p27在60例肺癌(鳞癌25例.腺癌20例，小细胞肺癌15例)和15例经手术证实、病理检测肺良性病变(炎性假瘤、局灶性肺脓肿、包裹性肺霉菌病、错构瘤和支气管腺瘤)正常细胞中的表达.结果 Skp2仅在肺癌组织中表达,且在吸烟者、鳞癌和低分化患者中过表达，而与患者年龄、性别、肿瘤位置和病理分期无关.p27在正常支气管上皮中均有表达,在肺癌中表达降低,但其表达仅与淋巴结转移和病理分期有关.Skp2阳性表达患者中.p27表达降低.结论 Skp2与p27蛋白的表达与肺癌的发生、发展有一定关系,在肺癌中二者存在某种相互作用机制.
목적 탐토S기단백격매상관단백(S-phase kinase-associated protein 2,Skp2)화p27단백재폐암중표체급림상의의.방법 응용면역조직화학S-P법검측Skp2화p27재60례폐암(린암25례.선암20례，소세포폐암15례)화15례경수술증실、병리검측폐량성병변(염성가류、국조성폐농종、포과성폐매균병、착구류화지기관선류)정상세포중적표체.결과 Skp2부재폐암조직중표체,차재흡연자、린암화저분화환자중과표체，이여환자년령、성별、종류위치화병리분기무관.p27재정상지기관상피중균유표체,재폐암중표체강저,단기표체부여림파결전이화병리분기유관.Skp2양성표체환자중.p27표체강저.결론 Skp2여p27단백적표체여폐암적발생、발전유일정관계,재폐암중이자존재모충상호작용궤제.
Objective To explore the expressions of S-phase kinase-associated protein 2(Skp2) and p27 protein and their significance in lung cancer. Methods The expressions of Skp2 and p27 protein were detected by immunohistochemical S-P method in samples from 60 patients with lung cancer and normal bronchial epithelial cells. Results Skp2 was only expressed in lung cancer and overexpressed in patients who smoke,and patients with squamous cell lung cancer and poorly differentiated lung cancer. The expression of p27 protein was found in normal bronchial epithilial cells and reduced in lung cancer correlated with pathology stage. The expression of p27 reduced in patients with positive expression of Skp2. Conclusions Skp2 overexpression and the reduction of p27 expression may be involved in the oncogenesis and development of lung cancer.