中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2012年
2期
207-209
,共3页
张焕珠%吴维寿%宿飞%孙超美%姜铭波%张国华%汪萱怡%徐志一
張煥珠%吳維壽%宿飛%孫超美%薑銘波%張國華%汪萱怡%徐誌一
장환주%오유수%숙비%손초미%강명파%장국화%왕훤이%서지일
血源乙肝疫苗%免疫效果
血源乙肝疫苗%免疫效果
혈원을간역묘%면역효과
Plasma-derived hepatitis B vaccine%Immunization
目的 观察血源乙型肝炎(乙肝)疫苗免疫的长期效果.方法 对上海市黄浦区1986年出生并接种乙肝疫苗的新生儿进行隔年随访,采血检测乙肝表面抗原(HBsAg)、乙肝表面抗体(抗-HBs)、乙肝核心抗体(抗-HBc),与本底对照(1984-1985年HBV横断面调查结果)以及外对照(1991年开展的相邻区域同年出生但未接种乙肝疫苗儿童调查的结果)相比计算保护效果.结果 随访队列23年间共计采集血液标本5993份,抗-HBs阳性率随免疫时间延长逐渐下降(从89.01%下降至18.77%),平均为40.39%;抗-HBc各年阳性率平均值在1.87%上下波动;HBsAg阳性率波动保持在1.00%(0.46% ~ 0.98%)以下,平均为0.62%(37/5993),与本底对照相比,各年龄组疫苗的保护效果在81.37% ~ 95.78%;与外对照相比,疫苗保护效果为72.76%.结论 血源乙肝疫苗中长期保护效果良好,免疫后23年无加强免疫的必要.
目的 觀察血源乙型肝炎(乙肝)疫苗免疫的長期效果.方法 對上海市黃浦區1986年齣生併接種乙肝疫苗的新生兒進行隔年隨訪,採血檢測乙肝錶麵抗原(HBsAg)、乙肝錶麵抗體(抗-HBs)、乙肝覈心抗體(抗-HBc),與本底對照(1984-1985年HBV橫斷麵調查結果)以及外對照(1991年開展的相鄰區域同年齣生但未接種乙肝疫苗兒童調查的結果)相比計算保護效果.結果 隨訪隊列23年間共計採集血液標本5993份,抗-HBs暘性率隨免疫時間延長逐漸下降(從89.01%下降至18.77%),平均為40.39%;抗-HBc各年暘性率平均值在1.87%上下波動;HBsAg暘性率波動保持在1.00%(0.46% ~ 0.98%)以下,平均為0.62%(37/5993),與本底對照相比,各年齡組疫苗的保護效果在81.37% ~ 95.78%;與外對照相比,疫苗保護效果為72.76%.結論 血源乙肝疫苗中長期保護效果良好,免疫後23年無加彊免疫的必要.
목적 관찰혈원을형간염(을간)역묘면역적장기효과.방법 대상해시황포구1986년출생병접충을간역묘적신생인진행격년수방,채혈검측을간표면항원(HBsAg)、을간표면항체(항-HBs)、을간핵심항체(항-HBc),여본저대조(1984-1985년HBV횡단면조사결과)이급외대조(1991년개전적상린구역동년출생단미접충을간역묘인동조사적결과)상비계산보호효과.결과 수방대렬23년간공계채집혈액표본5993빈,항-HBs양성솔수면역시간연장축점하강(종89.01%하강지18.77%),평균위40.39%;항-HBc각년양성솔평균치재1.87%상하파동;HBsAg양성솔파동보지재1.00%(0.46% ~ 0.98%)이하,평균위0.62%(37/5993),여본저대조상비,각년령조역묘적보호효과재81.37% ~ 95.78%;여외대조상비,역묘보호효과위72.76%.결론 혈원을간역묘중장기보호효과량호,면역후23년무가강면역적필요.
Objective To observe the long-term effect of plasma-derived HBV vaccine.Methods The effect of a plasma-derived HBV vaccine which was given to children born in 1986 in Huangpu district in Shanghai were followed up once every two years and testing for HBsAg,anti-HBs and anti-HBc was carried out.Compared to background results from cross-sectional survey of hepatitis B virus in 1984 and 1985 (as internal control) as well as finding of survey targeted in non-plasma-derived HBV vaccine of children born in the same time in the nearby area from results investigated in 1991 (as external control),positive rate was calculated to assess the effect of protection.Results The population immunized was followed up for 23 years and 5993 blood samples were collected.During the period of follow-up,the positive rate of anti-HBs decreased from 89.01% to 18.77% and the average level was 40.39%.The average positive rate of anti-HBc was 1.87%.The annual positive rate fluctuated around the average level.HBsAg positive rate remained less than 1.00% (0.46%-0.98%),with an average of 0.62% (37/5993).Ranges of positive efficacy were from 81.37% to 95.78% against background control and 72.76% against external control.Conclusion The plasma-derived HBV vaccine showed a good long-term protective effect and there was no need for boosting the immunization 23 years later.