中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2011年
3期
135-138
,共4页
假单胞菌,铜绿%抗药性%危险因素
假單胞菌,銅綠%抗藥性%危險因素
가단포균,동록%항약성%위험인소
Pseudomonas aeruginosa%Drug resistance%Risk factor
目的 研究重症监护病房(ICU)铜绿假单胞菌感染的发生率、危险因素及耐药情况.方法 收集171例脓毒症患者,分离培养铜绿假单胞菌并进行药敏试验.采用SPSS10.0统计学软件对可能的危险因素进行Logistic回归分析.结果 171例脓毒症患者中,发生铜绿假单胞菌感染37例,分离培养出 45株铜绿假单胞菌.多因素Logistic回归分析显示,近期抗菌药物使用史(OR=4.291,95%CI:1.727～10.662)、住ICU时间(OR=1.117,95%CI:1.058～1.181)、机械通气(OR=3.400,95%CI:1.348～8.579)以及中心静脉导管的使用(OR=3.339,95%CI:1.322～8.434)为铜绿假单胞菌感染的独立危险因素.药敏试验显示铜绿假单胞菌对头孢寨肟的耐药率最高(68.9%),18株(40%)菌株表现为多重耐药.结论 铜绿假单胞菌足ICU常见的病原菌,具有多重耐药性.加强抗菌药物的合理使用、严格执行各种有创导管的无菌操作是减少铜绿假单胞菌耐约的重要措施.
目的 研究重癥鑑護病房(ICU)銅綠假單胞菌感染的髮生率、危險因素及耐藥情況.方法 收集171例膿毒癥患者,分離培養銅綠假單胞菌併進行藥敏試驗.採用SPSS10.0統計學軟件對可能的危險因素進行Logistic迴歸分析.結果 171例膿毒癥患者中,髮生銅綠假單胞菌感染37例,分離培養齣 45株銅綠假單胞菌.多因素Logistic迴歸分析顯示,近期抗菌藥物使用史(OR=4.291,95%CI:1.727～10.662)、住ICU時間(OR=1.117,95%CI:1.058～1.181)、機械通氣(OR=3.400,95%CI:1.348～8.579)以及中心靜脈導管的使用(OR=3.339,95%CI:1.322～8.434)為銅綠假單胞菌感染的獨立危險因素.藥敏試驗顯示銅綠假單胞菌對頭孢寨肟的耐藥率最高(68.9%),18株(40%)菌株錶現為多重耐藥.結論 銅綠假單胞菌足ICU常見的病原菌,具有多重耐藥性.加彊抗菌藥物的閤理使用、嚴格執行各種有創導管的無菌操作是減少銅綠假單胞菌耐約的重要措施.
목적 연구중증감호병방(ICU)동록가단포균감염적발생솔、위험인소급내약정황.방법 수집171례농독증환자,분리배양동록가단포균병진행약민시험.채용SPSS10.0통계학연건대가능적위험인소진행Logistic회귀분석.결과 171례농독증환자중,발생동록가단포균감염37례,분리배양출 45주동록가단포균.다인소Logistic회귀분석현시,근기항균약물사용사(OR=4.291,95%CI:1.727～10.662)、주ICU시간(OR=1.117,95%CI:1.058～1.181)、궤계통기(OR=3.400,95%CI:1.348～8.579)이급중심정맥도관적사용(OR=3.339,95%CI:1.322～8.434)위동록가단포균감염적독립위험인소.약민시험현시동록가단포균대두포채우적내약솔최고(68.9%),18주(40%)균주표현위다중내약.결론 동록가단포균족ICU상견적병원균,구유다중내약성.가강항균약물적합리사용、엄격집행각충유창도관적무균조작시감소동록가단포균내약적중요조시.
Objective To investigate the incidence, risk factors and drug-resistance of Pseudomonas aeruginosa infection in intensive care unit (ICU). Methods Totally 171 patients with sepsis admitted in ICU were enrolled. Pathogenic bacteria culture and antimicrobial susceptibility tests were performed. SPSS10. 0 software was used for Logistic regression analysis of the risk factors. Results Pseudomonas aeruginosa infection was confirmed in 37 patients, and 45 strains of Pseudomonas aeruginosa were isolated. Logistic regression revealed that recent antibiotics use ( OR = 4. 291 , 95% CI: 1. 727-10. 662) , length of ICU stay (OR = 1.117, 95% CI: 1.058-1. 181) , mechanical ventilation (OR = 3.400, 95% CI: 1.348-8.579) and central venous catheterization (OR =3. 339, 95% CI: 1.322-8.434) were independent risk factors of Pseudomonas aeruginosa infection. The resistance rate of cefotaxime was the highest (68.9%) and 18 strains (40%) were multidrug-resistant. Conclusions Pseudomonas aeruginosa infection is common in ICU and it is usually multidrug resistant. The rational use of antibiotics and aseptic technique of invasive catheterization are important for the prevention of Pseudomonas aeruginosa infection.
