CAJ | 학술논문

目的探讨囊性纤维化跨膜电导调节子(CFTR)基因功能多态性IVS8-poly(T)与前列腺癌( PCa)风险的相关性.方法通过基于中国汉族人群的病例-对照研究,采用聚合酶链反应-短片段重复序列多态性( PCR-STRP)方法,对230例PCa患者和230名健康对照者的CFTR基因功能多态性位点IVS8-poly(T)进行基因分型,分析等位基因和基因型是否与PCa相关.结果病例组和对照组IVS8-5T等位基因频率分别为1.52％(7/460)和5.22％(24/460),差异有统计学意义(x2=12.489、P=0.002);Logistic回归分析显示5T/7T基因型携带者的PCa患病风险降低(OR=0.232,P=0.003,95％CI 0.090 ～ 0.599).结论 CFTR基因低表达型等位基因IVS8-5T与中国汉族男性PCa低风险有关,可能是PCa的一个保护性因素.
목적 탐토낭성섬유화과막전도조절자(CFTR)기인공능다태성IVS8-poly(T)여전렬선암( PCa)풍험적상관성.방법 통과기우중국한족인군적병례-대조연구,채용취합매련반응-단편단중복서렬다태성( PCR-STRP)방법,대230례PCa환자화230명건강대조자적CFTR기인공능다태성위점IVS8-poly(T)진행기인분형,분석등위기인화기인형시부여PCa상관.결과 병례조화대조조IVS8-5T등위기인빈솔분별위1.52％(7/460)화5.22％(24/460),차이유통계학의의(x2=12.489、P=0.002);Logistic회귀분석현시5T/7T기인형휴대자적PCa환병풍험강저(OR=0.232,P=0.003,95％CI 0.090 ～ 0.599).결론 CFTR기인저표체형등위기인IVS8-5T여중국한족남성PCa저풍험유관,가능시PCa적일개보호성인소.
Objective To investigate the association between functional polymorphism IVS8-poly (T) in cystic fibrosis transmembrane conductance regulator (CFTR) gene and prostate cancer risk.Methods A population-based case-control study was conducted including 230 prostate cancer patients and 230 agematched controls.PCR-STRP was used to analysis the IVS8-poly (T) tract in CFTR gene.Results The prevalences of the low expression allele,the IVS8-5T,in prostate cancer patients and controls were 1.52 ％ (7/460) and 5.22 ％ (24/460),respectively (x2 =12.489,P =0.002).Logistic regression analysis confirmed the 5T/7T genotype was in protective association with prostate cancer risk (OR =0.232,P =0.003,95 ％ CI0.090-0.599).Conclusion The low expression CFTR IVS8-5T allele contributes to a reduced risk of prostate cancer in Chinese Han population,and may be a protective factor against prostate cancer.