中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
14期
2083-2085
,共3页
胃肠肿瘤%窖蛋白-1%细胞周期素D1
胃腸腫瘤%窖蛋白-1%細胞週期素D1
위장종류%교단백-1%세포주기소D1
Gastrointestinal neoplasms%Caveolin-1%Cyclin D1
目的 探讨窖蛋白-1(Caveolin-1)和细胞周期素D1(cyclin D1)在胃腺癌组织中的表达及其临床病理意义,为胃癌判断预后及多途径治疗提供有效的试验依据.方法 采用免疫组织化学方法,检测120例胃腺癌和30例正常胃组织中Caveolin-1和cyclin D1的表达,分析两者与临床病理特征的关系及相关性.结果 胃癌组织中Caveolin-1表达降低、cyclin D1表达增多,与肿瘤分化程度、浸润深度、淋巴结转移和TNM分期相关,且两者的表达呈负相关(r=-0.297,P=0.001).结论 Caveolin-1和cyclin D1表达的负向协同可能与胃癌的发生、发展密切相关,两者可作为评价胃癌预后的指标,对胃癌的治疗有重要意义.
目的 探討窖蛋白-1(Caveolin-1)和細胞週期素D1(cyclin D1)在胃腺癌組織中的錶達及其臨床病理意義,為胃癌判斷預後及多途徑治療提供有效的試驗依據.方法 採用免疫組織化學方法,檢測120例胃腺癌和30例正常胃組織中Caveolin-1和cyclin D1的錶達,分析兩者與臨床病理特徵的關繫及相關性.結果 胃癌組織中Caveolin-1錶達降低、cyclin D1錶達增多,與腫瘤分化程度、浸潤深度、淋巴結轉移和TNM分期相關,且兩者的錶達呈負相關(r=-0.297,P=0.001).結論 Caveolin-1和cyclin D1錶達的負嚮協同可能與胃癌的髮生、髮展密切相關,兩者可作為評價胃癌預後的指標,對胃癌的治療有重要意義.
목적 탐토교단백-1(Caveolin-1)화세포주기소D1(cyclin D1)재위선암조직중적표체급기림상병리의의,위위암판단예후급다도경치료제공유효적시험의거.방법 채용면역조직화학방법,검측120례위선암화30례정상위조직중Caveolin-1화cyclin D1적표체,분석량자여림상병리특정적관계급상관성.결과 위암조직중Caveolin-1표체강저、cyclin D1표체증다,여종류분화정도、침윤심도、림파결전이화TNM분기상관,차량자적표체정부상관(r=-0.297,P=0.001).결론 Caveolin-1화cyclin D1표체적부향협동가능여위암적발생、발전밀절상관,량자가작위평개위암예후적지표,대위암적치료유중요의의.
Objective To investigate the expressions of Caveolin-1 and cyclin D1 and their significance in gastric cancer,and offer effective experiment evidence for the decision of gastric cancer prognosis and multitude pathway therapy.Methods The protein expression of Caveolin-1 and cyclin D1 were detected by immunohistochemistry in 120 cases of gastric cancer and 30 cases of normal gastric tissue.The correlations were analyzed between Caveolin1 and cyclin D1 expression and the clinicopathologic features of gastric cancer.Results The decreased expression of Caveolin-1 in gastric cancer may be negative correlated with tumorous differentiation degree,infiltration depth,lymphoid node metastasis and TNM stage;the increased expression of cyclin D1 in gastric cancer was positively correlated with tumorous differentiation degree,lymphoid node metastasis and TNM stage(r =- 0.297,P =0.001).Conclusion The expressions of Caveolin-1 and cyclin D1 were negatively correlated,and their negative synergy may be closely related to the occurrence,development and evolution of gastric cancer.Caveolin-1 and cyclin D1 were novel prognostic mark ers of gastric cancer,and may play an important role in the treatment of gastric cancer.
