CAJ | 학술논문

目的研究鼻腔鼻窦鳞状细胞癌和慢性鼻窦炎组织中Skp2和E2F1表达及其临床病理意义.方法 49例鼻腔鼻窦鳞状细胞癌、28例慢性鼻窦炎组织常规制作石蜡包埋切片,Spk2和E2F1免疫组化染色.结果鼻腔鼻窦鳞状细胞癌Skp2和E2F1表达阳性率及其评分明显高于慢性鼻窦炎组织(P<0.01);鼻腔鼻窦中分化鳞状细胞癌、肿块最大径≤3 cm、无淋巴结转移及未超出鼻腔鼻窦、侵犯周围组织的病例(临床分型T1N0M0)Skp2和E2F1表达阳性率及评分明显低于低分化鳞状细胞癌;肿块最大径>3 cm、有淋巴结转移及已超出鼻腔鼻窦侵犯周围组织的病例(临床分型T3N1M0、T3N2M0),两者差异有统计学意义(P<0.01);鼻腔鼻窦鳞状细胞癌组织中Skp2和E2F1表达呈正相关(r=0.623,P<0.01).结论 Skp2和E2F1表达可能是反映鼻腔鼻窦鳞状细胞癌发生、进展、生物学行为和预后的重要生物学标记物.
목적 연구비강비두린상세포암화만성비두염조직중Skp2화E2F1표체급기림상병리의의.방법 49례비강비두린상세포암、28례만성비두염조직상규제작석사포매절편,Spk2화E2F1면역조화염색.결과 비강비두린상세포암Skp2화E2F1표체양성솔급기평분명현고우만성비두염조직(P<0.01);비강비두중분화린상세포암、종괴최대경≤3 cm、무림파결전이급미초출비강비두、침범주위조직적병례(림상분형T1N0M0)Skp2화E2F1표체양성솔급평분명현저우저분화린상세포암;종괴최대경>3 cm、유림파결전이급이초출비강비두침범주위조직적병례(림상분형T3N1M0、T3N2M0),량자차이유통계학의의(P<0.01);비강비두린상세포암조직중Skp2화E2F1표체정정상관(r=0.623,P<0.01).결론 Skp2화E2F1표체가능시반영비강비두린상세포암발생、진전、생물학행위화예후적중요생물학표기물.
Objective To study the clinicopathological significance of Skp2 and E2F1 in the rhinosinus squamous cell carcinoma and chronic sinusitis. Methods Immunohistochemical method was used to detect the expression of Skp2 and E2F1 in the routinely paraffin-embed-ded sections of specimens from patients with rhinosinus squamoas cell carcinoma (n=49), chronic sinusitis (n=28). Results The expres-sive positive rates and scores of Skp2 and E2F1 in rhinosinus sqnamous cell carcinoma were significantly higher than those in chronic sinusitis (P<0.01). The expression positive rates and scores were significantly decreased in middle-differentiated rhinosinus squamous cell carcino-ma. The maximal diameter of mass was less than 3cm, and no-metastasis of lymphnode or no-infiltration of regional rhinosinus can be found in T1N0M0. While in the low-differentiated rhinosinus squamous cell carcinoma, the maximal diameter of mass was larger than 3cm, and metasta-sis of lymphnode or infiltration of regional rhinosinus can be found(T3N1M0,T3N2M0) (P<0.01). The closely positive correlation was found between the expression of Skp2 and E2F1 in the rhinosinus squamoas cell carcinoma. Conclusions Skp2 and E2F1 might be important biologi-cal markers for carcinogenesis, progression, biological behaviors and prognosis of rhinosinus squamous cell carcinoma.