CAJ | 학술논문

目的探讨MUM1/IRF4在滤泡性淋巴瘤(FL)中的表达情况及临床病理意义.方法对96例FL患者标本进行MUM1、CD10、bcl-2、bcl-6、Ki-67免疫组织化学染色,并与患者的临床资料和病理学特征比较.结果 MUM1在96例FL中总的阳性率为59.2%(58/96),其中1～2级组阳性率为36.2%(19/51),3级组阳性率为86.4%(39/45)(x2=24.406,P<0.001).68.9%伴有弥漫成分的FL患者MUM1阳性(x2=8.161,P=0.004).MUM1和CD10的表达呈负相关,83.3%的CD10阴性病例表达MUM1(x1=12.649,P<0.001).MUM1阳性者核分裂和Ki-67标记指数高于MUM1阴性者(t=-3.852、t=-4.610,P<0.001).结论 MUM1可作为FL分型的标志物.MUM1阳性的FL可能为类似非生发中心B细胞分化特征的高度恶性淋巴瘤.
목적 탐토MUM1/IRF4재려포성림파류(FL)중적표체정황급림상병리의의.방법 대96례FL환자표본진행MUM1、CD10、bcl-2、bcl-6、Ki-67면역조직화학염색,병여환자적림상자료화병이학특정비교.결과 MUM1재96례FL중총적양성솔위59.2%(58/96),기중1～2급조양성솔위36.2%(19/51),3급조양성솔위86.4%(39/45)(x2=24.406,P<0.001).68.9%반유미만성분적FL환자MUM1양성(x2=8.161,P=0.004).MUM1화CD10적표체정부상관,83.3%적CD10음성병례표체MUM1(x1=12.649,P<0.001).MUM1양성자핵분렬화Ki-67표기지수고우MUM1음성자(t=-3.852、t=-4.610,P<0.001).결론 MUM1가작위FL분형적표지물.MUM1양성적FL가능위유사비생발중심B세포분화특정적고도악성림파류.
Objective To clarify the MUM1/IRF4 expression in follicular lymphoma (FL) and its clinical and pathological significance. Methods Ninety-six cases FL were immunostained with MUM1,CD10,bcl-2,bcl-6 and Ki-67 antibodies. The results were compared with their clinical and pathological features. Results The overall MUM1 expression rate in FL was 59.2 % (58/96),including 36.2 % (19/51) grade 1 or 2 and 86.4 %(39/45) grade 3 cases (x2 =24.406,P <0.001). 68.9 % cases with diffuse area were MUM1 positive (x2 =8.161,P =0.004). MUM 1 and CD10 expression had inverse correlation,83.3 % CD10 negative cases were MUM1 positive (x2= 12.649,P<0.001). The mitosis rate and Ki-67 label index were statistically higher in MUM1 positive cases than in negative cases (t = -3.852 & -4.610,respectively,P <0.001). Conclusion MUM1 can be used as a biomarker to divide FL into different malignancies. The MUM1 positive FL may be the feature of high grade non germinal center B cell malignant lymphoma.