CAJ | 학술논문

目的研究2型糖尿病合并高血压患者与单纯2型糖尿病患者血浆D-二聚体浓度的不同.方法将85例研究对象分为3组:正常对照组:20例;无高血压的2型糖尿病组:21例;2型糖尿病合并高血压组:44例.测定其血浆D-二聚体浓度并比较组间差异,检测结果数据以均数±标准差表示,组间比较采用方差分析(使用SPSS 13.0软件).结果正常对照组血浆D-二聚体浓度为(102.15±32.48) μg/L,无高血压的2型糖尿病组为(148.62±80.99) μg/L,2型糖尿病合并高血压组为(206.28±92.99) μg/L,无高血压的2型糖尿病组与正常对照组比较,D-二聚体浓度明显升高,差异有统计学意义(P＜0.05);2型糖尿病合并高血压组与正常对照组比较,D-二聚体浓度也明显升高,差异有统计学意义(P＜0.01);无高血压的2型糖尿病组与合并高血压组比较差异有统计学意义(P＜0.05).结论血浆D-二聚体浓度在2型糖尿病及合并高血压患者中明显升高,这可能与凝血和纤溶系统失衡有关,在2型糖尿病及合并高血压患者中监测血浆D-二聚体浓度可能对于预防血栓性疾病有重要的临床意义.
목적 연구2형당뇨병합병고혈압환자여단순2형당뇨병환자혈장D-이취체농도적불동.방법 장85례연구대상분위3조:정상대조조:20례;무고혈압적2형당뇨병조:21례;2형당뇨병합병고혈압조:44례.측정기혈장D-이취체농도병비교조간차이,검측결과수거이균수±표준차표시,조간비교채용방차분석(사용SPSS 13.0연건).결과 정상대조조혈장D-이취체농도위(102.15±32.48) μg/L,무고혈압적2형당뇨병조위(148.62±80.99) μg/L,2형당뇨병합병고혈압조위(206.28±92.99) μg/L,무고혈압적2형당뇨병조여정상대조조비교,D-이취체농도명현승고,차이유통계학의의(P＜0.05);2형당뇨병합병고혈압조여정상대조조비교,D-이취체농도야명현승고,차이유통계학의의(P＜0.01);무고혈압적2형당뇨병조여합병고혈압조비교차이유통계학의의(P＜0.05).결론 혈장D-이취체농도재2형당뇨병급합병고혈압환자중명현승고,저가능여응혈화섬용계통실형유관,재2형당뇨병급합병고혈압환자중감측혈장D-이취체농도가능대우예방혈전성질병유중요적림상의의.
Objective To evaluate the plasma D-dimer level in the patients of type 2 diabetes mellitus with hypertension and investigate their correlation.Methods Eighty-five subjects were divided into three groups according to clinical manifestation:control group:20 subjects ; type 2 diabetes mellitus group:21 subjects; type 2 diabetes mellitus combined with hypertension group:44 subjects.The level of plasma D-dimer was measured and the difference was compared between groups.The results were showed as mean ± sd,and the difference was compared using ANOVA Test ( SPSS13.0).Results The plasma D-dimer concentrations in normal control group was ( 102.15 ± 32.48 ) μg/L,in single type 2 diabetes mellitus was ( 148.62 ± 80.99 ) μg/L,while plasma concentrations in type 2 diabetes mellitus combined with hypertension was ( 206.28 ± 92.99 ) μg/L.plasma D-dimer concentration was higher in single type 2 diabetes mellitus than that in normal control cases( P ＜0.05) ;And plasma D-dimer concentration was also found increased in type 2 diabetes mellitus combined with hypertension when compared with control group (P ＜ 0.01 ) ;And there was also significant difference on plasma D-dimer concentration between single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension cases ( P ＜ 0.05 ).Conclusion The plasma levels of D-dimer was increased obviously in single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension,it may be related to the imbalance of coagulation and fibrinolytic system.Monitoring of plasma D-dimer concentration in type 2 diabetes and patients with hypertension may have important clinical implications for the prevention of thrombotic diseases.