CAJ | 학술논문

目的探讨女性尖锐湿疣(CA)患者宫颈中人乳头瘤病毒(HPV)亚临床感染与CA复发的关系.方法根据临床及病理结果,收集107例女性CA患者及65例正常女性患者的宫颈拭子,将其分为高复发组(52例)、低复发组(55例)和正常对照组(65例),利用基因芯片技术检测患者宫颈中是否存在HPV病毒及其亚型,并进行统计学分析.结果高复发组中67.3%(35/52)例检测出HPV病毒,低复发组中34.5%(19/55)检测出HPV病毒,正常对照组4.6%(3/65)检测出HPV病毒,各组间差异有统计学意义.结论女性CA患者宫颈中存在HPV病毒感染的潜在病灶可能是CA复发的原因之一.
목적탐토녀성첨예습우(CA)환자궁경중인유두류병독(HPV)아림상감염여CA복발적관계.방법근거림상급병리결과,수집107례녀성CA환자급65례정상녀성환자적궁경식자,장기분위고복발조(52례)、저복발조(55례)화정상대조조(65례),이용기인심편기술검측환자궁경중시부존재HPV병독급기아형,병진행통계학분석.결과고복발조중67.3%(35/52)례검측출HPV병독,저복발조중34.5%(19/55)검측출HPV병독,정상대조조4.6%(3/65)검측출HPV병독,각조간차이유통계학의의.결론녀성CA환자궁경중존재HPV병독감염적잠재병조가능시CA복발적원인지일.
Objective To investigate the relationship between subclinical cervical HPV infection and recurrence of condyloma acuminatum (CA) in patients. Methods Cervical swabs were collected from 52 patients with frequently recurrent CA, 55 patients with infrequently recurrent CA, and 65 normal human controls. The Cenechip method was performed to detect the presence and type of HPV in cervical swabs followed by a statistical analysis. Results HPV was found in 67.3% (35/52) of swabs from patients with frequently recurrent CA, 5% (19/55) from patients with infrequently recurrent CA, and 4.6% (3/65) in the controls. There was a statistical difference among the three groups in the detection rate of HPV. Conclusion The subclinical cervical HPV infection may contribute to the recurrence of CA.