中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2010年
12期
853-857
,共5页
李传明%桂莉%杜寒剑%谢兵%王健
李傳明%桂莉%杜寒劍%謝兵%王健
리전명%계리%두한검%사병%왕건
遗忘%认知障碍%大脑皮质%磁共振成像
遺忘%認知障礙%大腦皮質%磁共振成像
유망%인지장애%대뇌피질%자공진성상
Amnesia%Cognition disorders%Cerebral cortex%Magnetic resonance imaging
目的 运用MRI及FMRIB software library(FSL)和Freesurfer软件包分析技术,研究遗忘型轻度认知功能损害(amnestic mild cognitive impairment,aMCI)患者全脑皮质结构改变情况.方法 对20例aMCI患者和20名年龄、性别、文化程度相匹配的健康志愿者,应用SEMENTS trio3.0 T MRI仪,采用高分辨扫描技术获取大脑精细结构立体像,然后应用FSL软件和Freesurfer软件包进行数据分析和后处理,计算出全脑不同部位皮质密度和厚度,比较aMCI组与健康对照组皮质结构特征的区别.结果 与健康对照组相比,aMCI组的左侧额叶、顶叶、颞叶皮质密度显著降低,右侧丘脑、颞叶及左侧岛叶皮质密度轻度降低;aMCI组左侧前扣带回[(2.19±0.24)mm]、顶下小叶[(2.27±0.15)mm],双侧海马旁回[(2.03±0.15)、(2.04±0.17)mm]、额上回[(2.42±0.34)、(2.40±0.28)mm]、额中回[(2.31±0.31)、(2.33±0.29)mm]、颞极[(3.41±0.68)、(3.30±0.56)mm]、颞横回[(2.04±0.12)、(2.01±0.11)mm]、中央前回[(2.20±0.11)、(2.31±0.19)mm]、中央后回[(1.88±0.11)、(1.82±0.09)mm]、缘上回[(2.53±0.33)、(2.55±0.23)mm]的皮质厚度显著降低(t=2.13～3.75,P＜0.05),其余部位无明显改变(t=0.09～1.88,P＞0.05).结论 aMCI患者大脑多个部位存在皮质结构改变,皮质厚度的变薄早于密度的降低.
目的 運用MRI及FMRIB software library(FSL)和Freesurfer軟件包分析技術,研究遺忘型輕度認知功能損害(amnestic mild cognitive impairment,aMCI)患者全腦皮質結構改變情況.方法 對20例aMCI患者和20名年齡、性彆、文化程度相匹配的健康誌願者,應用SEMENTS trio3.0 T MRI儀,採用高分辨掃描技術穫取大腦精細結構立體像,然後應用FSL軟件和Freesurfer軟件包進行數據分析和後處理,計算齣全腦不同部位皮質密度和厚度,比較aMCI組與健康對照組皮質結構特徵的區彆.結果 與健康對照組相比,aMCI組的左側額葉、頂葉、顳葉皮質密度顯著降低,右側丘腦、顳葉及左側島葉皮質密度輕度降低;aMCI組左側前釦帶迴[(2.19±0.24)mm]、頂下小葉[(2.27±0.15)mm],雙側海馬徬迴[(2.03±0.15)、(2.04±0.17)mm]、額上迴[(2.42±0.34)、(2.40±0.28)mm]、額中迴[(2.31±0.31)、(2.33±0.29)mm]、顳極[(3.41±0.68)、(3.30±0.56)mm]、顳橫迴[(2.04±0.12)、(2.01±0.11)mm]、中央前迴[(2.20±0.11)、(2.31±0.19)mm]、中央後迴[(1.88±0.11)、(1.82±0.09)mm]、緣上迴[(2.53±0.33)、(2.55±0.23)mm]的皮質厚度顯著降低(t=2.13～3.75,P＜0.05),其餘部位無明顯改變(t=0.09～1.88,P＞0.05).結論 aMCI患者大腦多箇部位存在皮質結構改變,皮質厚度的變薄早于密度的降低.
목적 운용MRI급FMRIB software library(FSL)화Freesurfer연건포분석기술,연구유망형경도인지공능손해(amnestic mild cognitive impairment,aMCI)환자전뇌피질결구개변정황.방법 대20례aMCI환자화20명년령、성별、문화정도상필배적건강지원자,응용SEMENTS trio3.0 T MRI의,채용고분변소묘기술획취대뇌정세결구입체상,연후응용FSL연건화Freesurfer연건포진행수거분석화후처리,계산출전뇌불동부위피질밀도화후도,비교aMCI조여건강대조조피질결구특정적구별.결과 여건강대조조상비,aMCI조적좌측액협、정협、섭협피질밀도현저강저,우측구뇌、섭협급좌측도협피질밀도경도강저;aMCI조좌측전구대회[(2.19±0.24)mm]、정하소협[(2.27±0.15)mm],쌍측해마방회[(2.03±0.15)、(2.04±0.17)mm]、액상회[(2.42±0.34)、(2.40±0.28)mm]、액중회[(2.31±0.31)、(2.33±0.29)mm]、섭겁[(3.41±0.68)、(3.30±0.56)mm]、섭횡회[(2.04±0.12)、(2.01±0.11)mm]、중앙전회[(2.20±0.11)、(2.31±0.19)mm]、중앙후회[(1.88±0.11)、(1.82±0.09)mm]、연상회[(2.53±0.33)、(2.55±0.23)mm]적피질후도현저강저(t=2.13～3.75,P＜0.05),기여부위무명현개변(t=0.09～1.88,P＞0.05).결론 aMCI환자대뇌다개부위존재피질결구개변,피질후도적변박조우밀도적강저.
Objective To investigate the cortex gray matter configuration in amnestic mild cognitive impairment(aMCI)patients using MRI technology, FMRIB software library(FSL)and Freesurfer software.Methods Twenty aMCI patients and 20 normal control subjects were recruited and studied. They were matched by age, sex and education. All the patients and healthy volunteers underwent MRI scan using SEMENTS trio 3.0 T MRI. The subtile three-dimensional brain images were obtained using high resolution scanning technique. The imaging data was processed and analyzed with FSL and Freesurfer software. The cortex gray matter density and thickness in different brain areas of aMCI patients and normal control subjects were calculated and compared using statistic analysis. Results Compared to that in the controls, cortex gray matter density in the aMCI patients showed remarkable decreases in left frontal lobe, temporal lobe,parietal lobe, and slight decrease in right thalamus, temporal lobe and island lobe; For cortex thickness,aMCI patients showed significant decreases in left anterior cingulate gyrus((2. 19 ±0. 24)mm), inferior parietal lobe((2. 27 ± 0. 15)mm), bilateral parahippocampal gyrus((2. 03 ± 0. 15),(2. 04 ±0. 17)mm), precentral gyrus((2. 20 ± 0. 11),(2. 31 ± 0. 19)mm), postcentral gyrus((1.88 ± 0. 11),(1.82 ± 0. 09)mm), superior frontal gyrus((2. 42 ± 0. 34),(2. 40 ± 0. 28)mm), middle frontal gyrus ((2.31±0.31),(2.33 ±0.29)mm), supramarginal gyrus((2.53 ±0.33),(2.55 ±0.23)mm),temporal pole((3.41 ±0.68),(3.30 ±0.56)mm)and transverse temporal gyrus((2.04 ±0. 12),(2. 01 ± 0. 11)mm; t = 2. 13-3.75, P ＜ 0. 05), no significant changes in the other areas(t = 0. 09-1.88, P ＞ 0. 05). Conclusions Our results suggest that there are significant changes in gray matter configuration in cortex of aMCl patients. The changes of cortical thickness is earlier than the changes of gray matter density.
