CAJ | 학술논문

目的观察多糖衍生物治疗骨质疏松的疗效.方法 40只6月龄雌性大鼠用维甲酸诱导产生骨质疏松模型,用多糖衍生物治疗.大鼠被随机分成两组,实验组每只每天口服10 mg多糖衍生物,对照组每只每天口服10 mg葡萄糖,通过形态学评估多糖衍生物的疗效.结果经多糖衍生物治疗后实验组大鼠平均骨小梁数、平均骨小梁厚度和平均骨小梁面积明显大于对照组(P<0.01).结论海藻多糖衍生物可增加骨重量,对维甲酸诱导产生骨质疏松有预防和治疗作用.
목적관찰다당연생물치료골질소송적료효.방법 40지6월령자성대서용유갑산유도산생골질소송모형,용다당연생물치료.대서피수궤분성량조,실험조매지매천구복10 mg다당연생물,대조조매지매천구복10 mg포도당,통과형태학평고다당연생물적료효.결과경다당연생물치료후실험조대서평균골소량수、평균골소량후도화평균골소량면적명현대우대조조(P<0.01).결론해조다당연생물가증가골중량,대유갑산유도산생골질소송유예방화치료작용.
Objective To observe the effect of marin algae polysaccharide derivant on the osteoporotic model of the rats. Methods Forty six-month-old female Wistar rats were selected to duplicate the osteoporotic model induced by retinoic acid and performed with marine algae polysaccharide derivant. The rats were randomly divided into two groups: experiment group treated with 10 mg marine algae polysaccharide derivant10mg per day by oral,control group treated with 10 mg glucose per day by oral.The effect of marine algae poly saccharide derivant on osteoporosis were evaluated by morphometry. Results After intake of polysaccharide,the mean trabecular plate density (Tb.N),the mean trabecular plate thickness(Tb.Th),and the percent trabecular area (Tb.Ar%) of t he experiment group, which were treated by polysaccharide were significantly increased more than that of the control group model(P<0.01). Conclusion These results indicate that polysaccharide can increase bone mass and has a therapeutic and preventional effect on the osteoporotic model of the rats induced by retinoic acid.