中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2007年
30期
6097-6099
,共3页
杨波%王广义%陈练%陈彬%覃容宾
楊波%王廣義%陳練%陳彬%覃容賓
양파%왕엄의%진련%진빈%담용빈
葡糖耐受不良%胰岛素抗药性%多囊卵巢综合征
葡糖耐受不良%胰島素抗藥性%多囊卵巢綜閤徵
포당내수불량%이도소항약성%다낭란소종합정
背景:胰岛素抵抗和胰岛素分泌异常是多囊卵巢综合征常见的并发症,胰岛素抵抗、糖耐量异常和糖尿病具有种族差异,决定了多囊卵巢综合征与胰岛素抵抗关系也存在种族差异.目的:分析藏族人群多囊卵巢综合征患者胰岛素抵抗与其体质量指数和血脂、血糖的关系.设计:病例分析.单位:解放军总医院心内科,西藏军区总医院内二科.对象:于2005-04/2006-04在西藏军区总医院内二科和妇科住院的藏族多囊卵巢综合征患者36名,年龄25～42岁,平均(32±5)岁.对照组36例,年龄24～35岁,平均(30±5)岁,为同时期同科住院的藏族非多囊卵巢综合征的患者.方法:采静脉血检测激素水平、空腹胰岛素、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇;超声检查卵巢.采集病史,记录一般情况,所有病例均接受75 g口服葡萄糖耐量试验.禁食12 h采静脉血检测空腹胰岛素、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇.胰岛素抵抗指标采用稳态模型计算,胰岛素抵抗指数=空腹胰岛素(mlU/L)×空腹血糖(mmol/L)/22.5.比较多囊卵巢综合征组与对照组观察对象的血压、体质量指数、血脂、血糖和胰岛素水平.主要观察指标:多囊卵巢综合征组与对照组观察对象血压、体质量指数、血脂、血糖和胰岛素水平.结果:36名多囊卵巢综合征患者和36名对照观察对象全部完成实验,中途无脱落.①多囊卵巢综合征患者的体质量指数、收缩压、舒张压高于对照组(t=3.426 5,2.4484,2.212 5,P＜0.05～0.01).②多囊卵巢综合征患者的总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平高于对照组(t=2.104 9,t=2.304 7,2.400 0,P＜0.05～0.01),高密度脂蛋白胆固醇低于对照组(t=4.800 0,P＜0.01).③多囊卵巢综合征组患者的空腹胰岛素、服糖后2 h血糖和胰岛素抵抗指数高于对照组(t=7.809 5,12.365 0,2.789 9,P＜0.01).结论:藏族多囊卵巢综合征患者呈现动脉粥样硬化危险因素聚集,如肥胖、血脂异常、高血压、高血糖等.
揹景:胰島素牴抗和胰島素分泌異常是多囊卵巢綜閤徵常見的併髮癥,胰島素牴抗、糖耐量異常和糖尿病具有種族差異,決定瞭多囊卵巢綜閤徵與胰島素牴抗關繫也存在種族差異.目的:分析藏族人群多囊卵巢綜閤徵患者胰島素牴抗與其體質量指數和血脂、血糖的關繫.設計:病例分析.單位:解放軍總醫院心內科,西藏軍區總醫院內二科.對象:于2005-04/2006-04在西藏軍區總醫院內二科和婦科住院的藏族多囊卵巢綜閤徵患者36名,年齡25～42歲,平均(32±5)歲.對照組36例,年齡24～35歲,平均(30±5)歲,為同時期同科住院的藏族非多囊卵巢綜閤徵的患者.方法:採靜脈血檢測激素水平、空腹胰島素、總膽固醇、三酰甘油、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇;超聲檢查卵巢.採集病史,記錄一般情況,所有病例均接受75 g口服葡萄糖耐量試驗.禁食12 h採靜脈血檢測空腹胰島素、總膽固醇、三酰甘油、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇.胰島素牴抗指標採用穩態模型計算,胰島素牴抗指數=空腹胰島素(mlU/L)×空腹血糖(mmol/L)/22.5.比較多囊卵巢綜閤徵組與對照組觀察對象的血壓、體質量指數、血脂、血糖和胰島素水平.主要觀察指標:多囊卵巢綜閤徵組與對照組觀察對象血壓、體質量指數、血脂、血糖和胰島素水平.結果:36名多囊卵巢綜閤徵患者和36名對照觀察對象全部完成實驗,中途無脫落.①多囊卵巢綜閤徵患者的體質量指數、收縮壓、舒張壓高于對照組(t=3.426 5,2.4484,2.212 5,P＜0.05～0.01).②多囊卵巢綜閤徵患者的總膽固醇、三酰甘油、低密度脂蛋白膽固醇水平高于對照組(t=2.104 9,t=2.304 7,2.400 0,P＜0.05～0.01),高密度脂蛋白膽固醇低于對照組(t=4.800 0,P＜0.01).③多囊卵巢綜閤徵組患者的空腹胰島素、服糖後2 h血糖和胰島素牴抗指數高于對照組(t=7.809 5,12.365 0,2.789 9,P＜0.01).結論:藏族多囊卵巢綜閤徵患者呈現動脈粥樣硬化危險因素聚集,如肥胖、血脂異常、高血壓、高血糖等.
배경:이도소저항화이도소분비이상시다낭란소종합정상견적병발증,이도소저항、당내량이상화당뇨병구유충족차이,결정료다낭란소종합정여이도소저항관계야존재충족차이.목적:분석장족인군다낭란소종합정환자이도소저항여기체질량지수화혈지、혈당적관계.설계:병례분석.단위:해방군총의원심내과,서장군구총의원내이과.대상:우2005-04/2006-04재서장군구총의원내이과화부과주원적장족다낭란소종합정환자36명,년령25～42세,평균(32±5)세.대조조36례,년령24～35세,평균(30±5)세,위동시기동과주원적장족비다낭란소종합정적환자.방법:채정맥혈검측격소수평、공복이도소、총담고순、삼선감유、고밀도지단백담고순、저밀도지단백담고순;초성검사란소.채집병사,기록일반정황,소유병례균접수75 g구복포도당내량시험.금식12 h채정맥혈검측공복이도소、총담고순、삼선감유、고밀도지단백담고순、저밀도지단백담고순.이도소저항지표채용은태모형계산,이도소저항지수=공복이도소(mlU/L)×공복혈당(mmol/L)/22.5.비교다낭란소종합정조여대조조관찰대상적혈압、체질량지수、혈지、혈당화이도소수평.주요관찰지표:다낭란소종합정조여대조조관찰대상혈압、체질량지수、혈지、혈당화이도소수평.결과:36명다낭란소종합정환자화36명대조관찰대상전부완성실험,중도무탈락.①다낭란소종합정환자적체질량지수、수축압、서장압고우대조조(t=3.426 5,2.4484,2.212 5,P＜0.05～0.01).②다낭란소종합정환자적총담고순、삼선감유、저밀도지단백담고순수평고우대조조(t=2.104 9,t=2.304 7,2.400 0,P＜0.05～0.01),고밀도지단백담고순저우대조조(t=4.800 0,P＜0.01).③다낭란소종합정조환자적공복이도소、복당후2 h혈당화이도소저항지수고우대조조(t=7.809 5,12.365 0,2.789 9,P＜0.01).결론:장족다낭란소종합정환자정현동맥죽양경화위험인소취집,여비반、혈지이상、고혈압、고혈당등.
BACKGROUND: Insulin resistance and impaired insulin secretion are the key complications of polycystic ovary syndrome (PCOS). The incidences of insulin resistance syndrome (IRS), impaired glucose tolerance (IGT) and diabetes mellitus have been clearly shown to be race-related, thus the association between polycystic ovary syndrome and insulin resistance was race-related.OBJECTIVE: To analyze the correlation of insulin resistance with body mass index (BMI), blood lipids and plasma glucose in Tibetan patients with PCOS.DESIGN: A prospective study based on Tibetan population.SETTING: Department of Cardiology, General Hospital of Chinese PLA; Second Department of Internal Medicine,General Hospital of Tibetan Military Area Command of Chinese PLA.PARTICIPANTS: Thirty-six Tibetan PCOS patients, aged 25-42 years with a mean age of (32±5) years were selected from the Second Department of Internal Medicine and Department of Gynecology, General Hospital of Tibetan Military Area Command of Chinese PLA. Another 36 female inpatients were selected as the controls (control group), aged 24-35 years with a mean age of (30±5) years.METHODS: The disease histories were collected and general conditions were recorded. Oral glucose tolerance test (OGTT, 75 g) was conducted for all the subjects. All the subjects werefasted for 12 hours to collect venous blood samples to detect the levels of hormone, fasting insulin, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Ovary was detected with echocardiography. The insulin resistance index was calculated by the homeostasis model assessment (HOMA-IR) was calculated by the formula:fasting insulin (mlU/L)×FPG (mmol/L)/22.5. The blood pressure, BMI and levels of blood lipids, plasma glucose and insulin were compared between the PCOS group and control group.MAIN OUTCOME MEASURES: Blood pressure, BMI and levels of blood lipids, plasma glucose and insulin were observed in both groups.RESULTS: All the 36 PCOS patients and 36 controls were involved in the analysis of final results. ① The BMI, systolic blood pressure and diastolic blood pressure in the PCOS group were higher than those in the control group (t =3.426 5,2.448 4, 2.212 5, P ＜ 0.05-0.01). ② The levels of total cholesterol, triglyceride and LDL-C in the PCOS group were higher than those in the control group (t=2.104 9, t =2.304 7, 2.400 0, P＜ 0.05-0.01), whereas the level of HDL-C was lower that in the control group (t =4.800 0, P＜ 0.01). ③ The levels of fasting insulin and 2-hour plasma glucose and HOM in the PCOS group were higher than those in the control group (t =7.809 5, 12.365 0, 2.789 9, P＜ 0.01).CONCLUSION: Tibetan PCOS patients present a clustering of atherosclerotic risk factors, including obesity, adverse lipid profile, hypertension, hyperglycemia, etc.
