CAJ | 학술논문

目的:探讨龈沟液中神经肽P物质(SP)与慢性牙周炎发生发展的关系.方法:研究组48 例,对照组45 例,研究组口内各选1 个牙周炎牙位、对照组各选1 个健康牙位收集龈沟液样本,采用放射免疫分析技术分别测定2 组龈沟液SP含量;记录牙龈指数(GI)、牙周袋探诊深度(PD)、附着丧失(AL)、牙槽骨吸收(ABL)情况,并进行与SP的相关性分析.结果:研究组SP含量显著高于对照组(t＝9.92,P<0.01);轻度牙周炎SP含量及牙周临床指标与对照组相比,均有显著差异(P<0.01);轻度牙周炎龈沟液SP含量与GI无显著相关性,但与PD、AL、ABL之间,以及中、重度牙周炎龈沟液SP含量与GI之间,均呈显著性相关(P＜0.05);中、重度牙周炎SP含量与PD、AL、ABL之间均呈非常显著性相关(P<0.01).结论:龈沟液中SP含量与慢性牙周炎的发生发展密切相关,可以反映牙周组织的破坏程度;测定患者龈沟液中SP含量,对于判断病情、指导治疗具有重要意义.
목적:탐토간구액중신경태P물질(SP)여만성아주염발생발전적관계.방법:연구조48 례,대조조45 례,연구조구내각선1 개아주염아위、대조조각선1 개건강아위수집간구액양본,채용방사면역분석기술분별측정2 조간구액SP함량;기록아간지수(GI)、아주대탐진심도(PD)、부착상실(AL)、아조골흡수(ABL)정황,병진행여SP적상관성분석.결과:연구조SP함량현저고우대조조(t＝9.92,P<0.01);경도아주염SP함량급아주림상지표여대조조상비,균유현저차이(P<0.01);경도아주염간구액SP함량여GI무현저상관성,단여PD、AL、ABL지간,이급중、중도아주염간구액SP함량여GI지간,균정현저성상관(P＜0.05);중、중도아주염SP함량여PD、AL、ABL지간균정비상현저성상관(P<0.01).결론:간구액중SP함량여만성아주염적발생발전밀절상관,가이반영아주조직적파배정도;측정환자간구액중SP함량,대우판단병정、지도치료구유중요의의.
Objective: To study the relationship between occurrence and development of chronic periodontitis and neuropeptide substance P (SP) in gingival crevicular fluid. Methods: There were 48 patients in experimental group and 42 patients in the control group. Gingival crevicular fluid samples were collected from the patients′ intraoral chronic periodontitis inflammatory positive sites and healthy sites. Neuropeptide substance P levels in gingival crevicular fluid from two groups were measured by radioimmunoassay. Gingival index, pocket depth, attachment loss, alveolar bone resorption were recorded and their correlations with SP were analyzed. Results: SP levels of the experimental group were significantly higher than those of the control group(P<0.01). There were significant differences(P<0.01)between SP level and periodontal clinical index in slight periodontitis and the control group. There were significant correlations(P<0.05)between GCF SP content and all PD, AL, ABL but GI in slight periodontitis, and there were significant correlations in between GCF SP content and GI for both moderate periodontitis and severe periodontitis. There were significant correlations(P<0.01) between GCF SP content and PD,AL,ABL for both moderate periodontitis and severe periodontitis. Conclusion:GCF SP level is closely related to occurrence and development of chronic periodontitis.GCF SP level can reflect the degree of the damage of periodontium.Determination of patients′ GCF SP level has important significance for the patients′ condition judgement and treatment guidance.