中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2010年
8期
614-616
,共3页
25羟维生素D3%糖尿病,2型%早相胰岛素分泌
25羥維生素D3%糖尿病,2型%早相胰島素分泌
25간유생소D3%당뇨병,2형%조상이도소분비
25-OH vitamin D3%Diabetes mellitus,type 2%Earlyphase insulin secretion
目的 探讨老年2型糖尿病(T2DM)患者血25羟维生素D3(VD3)水平与早相胰岛素分泌的关系.方法 选择老年DM前期40例为A组、新诊断T2DM 40例为B组、经治T2DM 50例为C组、老年健康者50名为对照(NC)组.ELISA法测定血VD3,以△I30/△G30及HOMA-β反映早相胰岛素分泌功能.结果 从NC到A、B及C组,随糖代谢紊乱的逐渐加重,VD3水平逐渐降低(P均<0.05).130例糖代谢异常患者随VD3水平逐渐增高,早相胰岛素分泌功能逐渐好转(P均<0.05);反之,随早相胰岛素分泌功能逐渐好转,VD3水平逐渐增高(P均<0.05).回归分析显示,VD3与早相胰岛素分泌功能呈正相关(P均<0.05).结论 老年T2DM患者存在VD3缺乏,可能是导致其早相胰岛素分泌功能障碍的因素之一.
目的 探討老年2型糖尿病(T2DM)患者血25羥維生素D3(VD3)水平與早相胰島素分泌的關繫.方法 選擇老年DM前期40例為A組、新診斷T2DM 40例為B組、經治T2DM 50例為C組、老年健康者50名為對照(NC)組.ELISA法測定血VD3,以△I30/△G30及HOMA-β反映早相胰島素分泌功能.結果 從NC到A、B及C組,隨糖代謝紊亂的逐漸加重,VD3水平逐漸降低(P均<0.05).130例糖代謝異常患者隨VD3水平逐漸增高,早相胰島素分泌功能逐漸好轉(P均<0.05);反之,隨早相胰島素分泌功能逐漸好轉,VD3水平逐漸增高(P均<0.05).迴歸分析顯示,VD3與早相胰島素分泌功能呈正相關(P均<0.05).結論 老年T2DM患者存在VD3缺乏,可能是導緻其早相胰島素分泌功能障礙的因素之一.
목적 탐토노년2형당뇨병(T2DM)환자혈25간유생소D3(VD3)수평여조상이도소분비적관계.방법 선택노년DM전기40례위A조、신진단T2DM 40례위B조、경치T2DM 50례위C조、노년건강자50명위대조(NC)조.ELISA법측정혈VD3,이△I30/△G30급HOMA-β반영조상이도소분비공능.결과 종NC도A、B급C조,수당대사문란적축점가중,VD3수평축점강저(P균<0.05).130례당대사이상환자수VD3수평축점증고,조상이도소분비공능축점호전(P균<0.05);반지,수조상이도소분비공능축점호전,VD3수평축점증고(P균<0.05).회귀분석현시,VD3여조상이도소분비공능정정상관(P균<0.05).결론 노년T2DM환자존재VD3결핍,가능시도치기조상이도소분비공능장애적인소지일.
Objective To study the relationship between the level of VD3 and earlyphase insulin secretion in elderly patients with T2DM. Methods The 40 newly diagnosed T2DM subjects，50 treated T2DM subjects，40 IGT/IFG subjects and 40 healthy subjects were divided into A、B、C and control group respectively. The serum level of VD3 was determined by ELISA.And OGTT, △I30/△G30 ratio and HOMA-β were done and calculated. Results The levels of VD3，△I30/△G30 and HOMA-β were higher in study groups than in control group（all P<0.05）.The regression correlation analysis showed the positive correlation of VD3 level with △I30/△G30ratio and HOMA-β（r=0.40,r=0.29 respectively，all P<0.05）. Conclusions The elderly patients with T2DM have lower VD3 levels，which may be one of factors resulting in the impaired early phase insulin secretion.
