CAJ | 학술논문

树突细胞相关凝集素2(Dectin-2)是一种新发现的c型凝集素受体,具有一个碳水化合物识别域CRD,可识别高甘露糖结构,广泛存在于树突状细胞等固有免疫细胞表面.由于其具有抗真菌病原体感染和紫外线诱导耐受等作用,因此在机体的免疫系统中发挥重要作用.对于Dectin-2等c型凝集素受体的深入研究将有利于我们对微生物感染、肿瘤免疫和自身免疫等方面有更深入的认识,从而对预防和治疗疾病起着指导作用.
수돌세포상관응집소2(Dectin-2)시일충신발현적c형응집소수체,구유일개탄수화합물식별역CRD,가식별고감로당결구,엄범존재우수돌상세포등고유면역세포표면.유우기구유항진균병원체감염화자외선유도내수등작용,인차재궤체적면역계통중발휘중요작용.대우Dectin-2등c형응집소수체적심입연구장유리우아문대미생물감염、종류면역화자신면역등방면유경심입적인식,종이대예방화치료질병기착지도작용.
Dectin-2 is a dendritic cell-related C-type with one carbohydrate-recognition domain(CRD).which can recognise the high-mannose structure.It plays an important role in the innate immune system because of its antifungus capasity and its role in UV-induced tolerance.Further study on Dectin-2 and other C-type lectin receptors will allow us to have a deep understanding in the prevention and treatment of microbial infection.tumor immunity and autoimmunity.