国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2011年
2期
139-142
,共4页
TGF-β%Foxp3%CD4+ CD25+调节性T细胞%诱导
TGF-β%Foxp3%CD4+ CD25+調節性T細胞%誘導
TGF-β%Foxp3%CD4+ CD25+조절성T세포%유도
TGF-β%Foxp3%CD4 + CD25 + regulatory T cells%induce
CD4+CD25+调节性T细胞(CD4+CD25+Treg)是一类具有免疫调节功能的淋巴细胞,在维持机体免疫耐受和免疫应答稳态方面发挥重要作用.转化生长因子β(TGF-β)与CD4+CD25+Treg的发育分化和功能有着密不可分的关系,虽然作用机理尚不完全明了,但其重要性毋庸置疑.
CD4+CD25+調節性T細胞(CD4+CD25+Treg)是一類具有免疫調節功能的淋巴細胞,在維持機體免疫耐受和免疫應答穩態方麵髮揮重要作用.轉化生長因子β(TGF-β)與CD4+CD25+Treg的髮育分化和功能有著密不可分的關繫,雖然作用機理尚不完全明瞭,但其重要性毌庸置疑.
CD4+CD25+조절성T세포(CD4+CD25+Treg)시일류구유면역조절공능적림파세포,재유지궤체면역내수화면역응답은태방면발휘중요작용.전화생장인자β(TGF-β)여CD4+CD25+Treg적발육분화화공능유착밀불가분적관계,수연작용궤리상불완전명료,단기중요성무용치의.
CD4 + CD25 + regulatory T cells (CD4 + CD25 + Treg) are a type of T lymphocytes that function in immune regulation and play a major role in maintaining the homeostasis of immune tolerance and immune response. Transforming growth factor β (TGF-β), an important cytokine, plays a critical role in the development, differentiation and function of Treg. However, the exact mechanism throught which TGF-β funcitions has not been completely understood. The role and influencing factors of TGF-3 to the development and differentiation of Treg are summarized in this review.
