中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2010年
6期
465-467
,共3页
李会娟%施毕旻%赵小娟%沈文红%阮长耿
李會娟%施畢旻%趙小娟%瀋文紅%阮長耿
리회연%시필민%조소연%침문홍%원장경
糖尿病%血管病变%微颗粒%内皮细胞功能异常
糖尿病%血管病變%微顆粒%內皮細胞功能異常
당뇨병%혈관병변%미과립%내피세포공능이상
Diabetes mellitus%Angiopathy%Microparticles%Endothelial dysfunction
目的 分析糖尿病患者微颗粒(包括血小板微颗粒、内皮细胞微颗粒以及组织因子阳性微颗粒)水平,探讨微颗粒水平与糖尿病并发症的相关性.方法 流式细胞仪检测106例糖尿病患者和50例健康志愿者血浆中血小板微颗粒、内皮细胞微颗粒和组织因子阳性微颗粒水平,并比较糖尿病血管病变各组间微颗粒的变化.结果 糖尿病组血小板微颗粒和组织因子阳性微颗粒水平与对照组比较无明显差异(23.09±15.66对38.55±28.56,83.82±82.61对89.06±82.75,均P>0.05),而内皮细胞微颗粒水平在糖尿病组明显高于对照组(164.20±128.88对63.81±40.84,P<0.05),合并有血管病变者其内皮细胞微颗粒水平又高于单纯糖尿病组(184.12±152.77、188.21±149.55对138.53±99.87,P<0.05).结论 内皮细胞功能异常是糖尿病患者,尤其合并有血管病变患者内皮细胞微颗粒升高的原因;内皮细胞微颗粒水平可以用来评价糖尿病患者血管内皮细胞的功能状态和疾病的进展的指标之一.
目的 分析糖尿病患者微顆粒(包括血小闆微顆粒、內皮細胞微顆粒以及組織因子暘性微顆粒)水平,探討微顆粒水平與糖尿病併髮癥的相關性.方法 流式細胞儀檢測106例糖尿病患者和50例健康誌願者血漿中血小闆微顆粒、內皮細胞微顆粒和組織因子暘性微顆粒水平,併比較糖尿病血管病變各組間微顆粒的變化.結果 糖尿病組血小闆微顆粒和組織因子暘性微顆粒水平與對照組比較無明顯差異(23.09±15.66對38.55±28.56,83.82±82.61對89.06±82.75,均P>0.05),而內皮細胞微顆粒水平在糖尿病組明顯高于對照組(164.20±128.88對63.81±40.84,P<0.05),閤併有血管病變者其內皮細胞微顆粒水平又高于單純糖尿病組(184.12±152.77、188.21±149.55對138.53±99.87,P<0.05).結論 內皮細胞功能異常是糖尿病患者,尤其閤併有血管病變患者內皮細胞微顆粒升高的原因;內皮細胞微顆粒水平可以用來評價糖尿病患者血管內皮細胞的功能狀態和疾病的進展的指標之一.
목적 분석당뇨병환자미과립(포괄혈소판미과립、내피세포미과립이급조직인자양성미과립)수평,탐토미과립수평여당뇨병병발증적상관성.방법 류식세포의검측106례당뇨병환자화50례건강지원자혈장중혈소판미과립、내피세포미과립화조직인자양성미과립수평,병비교당뇨병혈관병변각조간미과립적변화.결과 당뇨병조혈소판미과립화조직인자양성미과립수평여대조조비교무명현차이(23.09±15.66대38.55±28.56,83.82±82.61대89.06±82.75,균P>0.05),이내피세포미과립수평재당뇨병조명현고우대조조(164.20±128.88대63.81±40.84,P<0.05),합병유혈관병변자기내피세포미과립수평우고우단순당뇨병조(184.12±152.77、188.21±149.55대138.53±99.87,P<0.05).결론 내피세포공능이상시당뇨병환자,우기합병유혈관병변환자내피세포미과립승고적원인;내피세포미과립수평가이용래평개당뇨병환자혈관내피세포적공능상태화질병적진전적지표지일.
Objective To investigate the levels of mieropartieles originated from platelet (PMP),endothelium (EMP),and tissue factor-bearing microparticles (TF+ MP) in diabetes mellitus and to analyze its relationship with diabetic angiopathy.Methods PMP,EMP or TF+ MP were measured in 106 cases of diabetes mellitus and 50 controls by flow eytometry.The differences of EMP between groups of diabetic macrovascular disease and diabetic microvascular disease were determined.Results The levels of EMP in diabetic patients were higher than that in the control(164.20±128.88 vs 63.81±40.84,P<0.05).Diabetic cases with complication showed higher expression level of EMP than those without complications(184.12±152.77,188.21±149.55 vs 138.53±99.87,both P<0.05).However,no distinct increase was observed in PMP and TF+ MP level in diabetes groups compared with control group.Conclusions Endothelial dysfunction,may contribute to the increased level of EMP in patients with diabetes,especially those complicated with vascular diseases.EMP level may be used to evaluate the status of endothelial function and the development of diabetic angiopathy.
