CAJ | 학술논문

目的观察胰腺癌的神经浸润状况,分析与其相关的临床因素.方法回顾性分析73例胰腺癌患者的神经浸润状况,分析神经浸润与肿瘤临床病理特征及患者生存率之间的关系.结果 73例中38例(52.1％)有神经浸润,其中6例(15.8％)为单纯胰内神经浸润,32例(84.2％)为胰内、胰外神经均浸润.神经浸润与患者性别、年龄及肿瘤病理类型、分化程度、大小、淋巴结转移均无关(P值均＞0.05),而与腹痛、脉管浸润、肿瘤组织表皮生长因子受体(EGFR)及血管内皮生长因子(VEGF)表达均显著相关(P值均＜0.01).有神经浸润患者的中位生存时间为8个月,显著短于无神经浸润患者的13个月(x2=4.69,P=0.030).结论胰腺癌的神经浸润发生率较高,可引起明显腹痛,其与脉管浸润及肿瘤组织EGFR和VEGF表达相关,是影响胰腺癌患者术后生存率的因素之一.
목적 관찰이선암적신경침윤상황,분석여기상관적림상인소.방법 회고성분석73례이선암환자적신경침윤상황,분석신경침윤여종류림상병리특정급환자생존솔지간적관계.결과 73례중38례(52.1％)유신경침윤,기중6례(15.8％)위단순이내신경침윤,32례(84.2％)위이내、이외신경균침윤.신경침윤여환자성별、년령급종류병리류형、분화정도、대소、림파결전이균무관(P치균＞0.05),이여복통、맥관침윤、종류조직표피생장인자수체(EGFR)급혈관내피생장인자(VEGF)표체균현저상관(P치균＜0.01).유신경침윤환자적중위생존시간위8개월,현저단우무신경침윤환자적13개월(x2=4.69,P=0.030).결론 이선암적신경침윤발생솔교고,가인기명현복통,기여맥관침윤급종류조직EGFR화VEGF표체상관,시영향이선암환자술후생존솔적인소지일.
Objective To study the situation of neural invasion in pancreatic cancer and investigate its related clinical factors. Methods The neural invasion in 73 cases of pancreatic cancer patients was retrospective analysed. The correlation between neural invasion and clinicopathological parameters,and survival rate was investigated.Results In 73 cases of pancreatic cancer,neural invasion occurred in 38(52.1％) patients,among whom intra-pancreatic neural invasion rate was 15.8％ (n =6) ; and both intrapancreatic and external pancreatic plexus invasion rate was 84.2％ ( n =32).Neural invasion was not related with gender,age,and pathological type,degree of differentiation,tumor size and lymph node metastasis (P ＞ 0.05 ).But the presence of abdominal pain,vascular invasion,the expression of EGFR and VEGF in tumor tissue was significantly related with neural invasion (P ＜0.01 ).The median survival of patients in neural invasion group was 8 months,which were significantly shorter than that of in patients without neural invasion (13 months,x2 =4.69,P =0.030).Conclusions Neural invasion has a high incidence in pancreatic cancer,and it can cause obvious abdominal pain.And it is related with vascular invasion and the expression of EGFR and VEGF in tumor tissue.Neural invasion is one of the factors affecting the survival rate.