CAJ | 학술논문

目的探讨幽门螺杆菌(Hp)感染及谷胱甘肽转硫酶P1(GSTP1)基因多态性与胃癌的关系.方法选择老年胃癌患者(胃癌组)98例和胃镜检查正常者(对照组)149例,以快速尿素酶试验、13C-尿素呼气试验或活检标本吉姆萨染色(Giemsa)检测Hp感染;通过聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)分析方法检测GSTP1基因型.结果 Hp感染率胃癌组(54.1%)与对照组(40.9%)比较,差异有统计学意义(x2=4.11,P＜0.05);具有GSTP1突变纯和基因型并有Hp感染阳性的人群胃癌发病风险显著增加OR值5.44(1.26～26.79)(x2=7.13,P＜0.01).结论老年患者Hp感染和GSTP1基因型多态性与胃癌的发病风险有关.
목적 탐토유문라간균(Hp)감염급곡광감태전류매P1(GSTP1)기인다태성여위암적관계.방법 선택노년위암환자(위암조)98례화위경검사정상자(대조조)149례,이쾌속뇨소매시험、13C-뇨소호기시험혹활검표본길모살염색(Giemsa)검측Hp감염;통과취합매련식반응-한제성편단장도다태성(PCR-RFLP)분석방법검측GSTP1기인형.결과 Hp감염솔위암조(54.1%)여대조조(40.9%)비교,차이유통계학의의(x2=4.11,P＜0.05);구유GSTP1돌변순화기인형병유Hp감염양성적인군위암발병풍험현저증가OR치5.44(1.26～26.79)(x2=7.13,P＜0.01).결론 노년환자Hp감염화GSTP1기인형다태성여위암적발병풍험유관.
Objective To study the relationships of Helicobacter pylori (Hp) infection and genetic polymorphisms of glutathione s-transferase P1 (GSTP1) with gastric cancer (GC). Methods The 98 patients with GC and 149 controls with normal finding at endoscopy were enrolled for this study. The rapid urease test (RUT), 13C- urea breath test (13C-UBT) and Giemsa staining of biopsy samples were used to check Hp infection. PCR-based restriction fragment length polymorphisms (PCR-RFLP) was used to detect GSTP1 genotype. Results The rate of Hp infection was higher in GC group than in control group (54.1% vs. 40.9%, x2 =4.11, P＜0. 05). The risk of GC would significantly increase in the GSTP1 homozygous mutant gene (MM) group with Hp infection (OR=5.44, 95%CI 1. 26-26. 79, x2=7.13, P＜0.05). Conclusions Hp infection and GSTP1 genetic polymorphisms are associated with gastric cancer risk in the elderly.