中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2011年
6期
355-357
,共3页
庄让笑%周红萍%梁伟峰%邵益丹
莊讓笑%週紅萍%樑偉峰%邵益丹
장양소%주홍평%량위봉%소익단
肝炎,丙型,慢性%干扰素类%利巴韦林%病毒学应答
肝炎,丙型,慢性%榦擾素類%利巴韋林%病毒學應答
간염,병형,만성%간우소류%리파위림%병독학응답
Chronic hepatitis C%Inferferons%Ribavirin%Virological response
目的 比较慢性丙型肝炎患者接受聚乙二醇干扰素α( Peg IFNα) -2a或Peg IFNα-2b联合利巴韦林治疗后的疗效差异.方法 对46例慢性丙型肝炎(CHC)患者进行回顾性分析,将患者分为2组,Peg IFNα-2a组24例,每周1次皮下注射Peg IFNα-2a 180μg,Peg IFNα-2b组22例,1.5 μg ·kg-1·周-1,2组均l司时服用利巴韦林.在治疗的第4、12和24周检测患者血清HCV RNA载量评估病毒学应答情况.采用SPSS13.0和PEMS3.1软件进行分析.结果 两组患者治疗后快速病毒学应答、早期病毒学应答、完全应答和无应答率差异无统计学意义(x2=0.689、0.105、0.105和0.105,P＜0.05).基线HCV RNA ＞6 logl0拷贝/mL的患者中,使用Peg IFNα-2a治疗的快速病毒学应答率为86.67％,高于使用Peg IFNα-2b治疗的快速病毒学应答率(42.86％)(x2=4.365,P＜0.05).结论 Peg IFNα-2a联合利巴韦林治疗慢性丙型肝炎的快速病毒学应答率优于Peg IFNα-2b.
目的 比較慢性丙型肝炎患者接受聚乙二醇榦擾素α( Peg IFNα) -2a或Peg IFNα-2b聯閤利巴韋林治療後的療效差異.方法 對46例慢性丙型肝炎(CHC)患者進行迴顧性分析,將患者分為2組,Peg IFNα-2a組24例,每週1次皮下註射Peg IFNα-2a 180μg,Peg IFNα-2b組22例,1.5 μg ·kg-1·週-1,2組均l司時服用利巴韋林.在治療的第4、12和24週檢測患者血清HCV RNA載量評估病毒學應答情況.採用SPSS13.0和PEMS3.1軟件進行分析.結果 兩組患者治療後快速病毒學應答、早期病毒學應答、完全應答和無應答率差異無統計學意義(x2=0.689、0.105、0.105和0.105,P＜0.05).基線HCV RNA ＞6 logl0拷貝/mL的患者中,使用Peg IFNα-2a治療的快速病毒學應答率為86.67％,高于使用Peg IFNα-2b治療的快速病毒學應答率(42.86％)(x2=4.365,P＜0.05).結論 Peg IFNα-2a聯閤利巴韋林治療慢性丙型肝炎的快速病毒學應答率優于Peg IFNα-2b.
목적 비교만성병형간염환자접수취을이순간우소α( Peg IFNα) -2a혹Peg IFNα-2b연합리파위림치료후적료효차이.방법 대46례만성병형간염(CHC)환자진행회고성분석,장환자분위2조,Peg IFNα-2a조24례,매주1차피하주사Peg IFNα-2a 180μg,Peg IFNα-2b조22례,1.5 μg ·kg-1·주-1,2조균l사시복용리파위림.재치료적제4、12화24주검측환자혈청HCV RNA재량평고병독학응답정황.채용SPSS13.0화PEMS3.1연건진행분석.결과 량조환자치료후쾌속병독학응답、조기병독학응답、완전응답화무응답솔차이무통계학의의(x2=0.689、0.105、0.105화0.105,P＜0.05).기선HCV RNA ＞6 logl0고패/mL적환자중,사용Peg IFNα-2a치료적쾌속병독학응답솔위86.67％,고우사용Peg IFNα-2b치료적쾌속병독학응답솔(42.86％)(x2=4.365,P＜0.05).결론 Peg IFNα-2a연합리파위림치료만성병형간염적쾌속병독학응답솔우우Peg IFNα-2b.
Objective To compare the virological responses between Peg IFNαt-2a and Peg IFNα-2b in treatment of chronic hepatitis C.Methods Clinical data of 46 chronic hepatitis C (CHC) patients were retrospectively reviewed.Patients were divided into two groups:Peg IFNα-2a group ( n =24) was given Peg IFNoα-2a 180 μg/week and ribavirin; Peg IFNα-2b group (n =22 ) was given Peg IFNα-2b1.5 μg · kg-1 · week-1 and ribavirin.Serum HCV RNA load at 4th,12th and 24th week of the treatment were detected to evaluate the virological responses.Softwares SPSS 13.0 and PEMS 3.1 were used for statistical analysis.Results There was no significant difference in rapid response rate,early response rate,complete response rate and non-response rate between the two groups (x2 =0.689,0.105,0.105 and 0.105,P ＞ 0.05 ).However for patients with high viral load ( HCV RNA ＞ 6 logl0 copies/mL) at baseline,the rapid response rate in Peg IFNα-2a group ( 86.67％ ) was higher than that in Peg IFNα-2bgroup (42.86％ ) (x2 =4.365,P ＜ 0.05 ).Conclusion Peg IFNα-2a combined with ribavirin may have higher rapid response rate than that of Peg IFNα-2b combined with ribavirin in CHC patients with high viral
