CAJ | 학술논문

目的探讨糖调节受损人群发生糖尿病的危险性及其影响因素.方法 2002年6月至8月,采用抽样分层横断面现场调查方法于上海市浦东新区社区中检出192例糖调节受损者.2007年同期进行随访,观察单纯糖耐量受损、单纯空腹血糖受损、糖耐量受损合并空腹血糖受损、糖尿病人群比例,变化.使用t检验、方差分析、卡方检验进行统计学分析.结果 5年中死亡5例,存活的187例中79例发生糖尿病,糖尿病年转化率为8.4%(79/187/5年).基线单纯糖耐量受损者糖尿病年转化率为8.2%(47/114/5年),基线单纯空腹血糖受损者精尿病年转化率为6.3%(12/38/5年),基线糖耐量受损合并空腹血糖受损者糖尿病年转化率为11.4%(20/35/5年).正常糖耐量年转化率为6.3%(59/187/5年).单纯糖耐量受损者和糖耐量受损合并空腹血糖受损者发生糖尿病的风险分别是单纯空腹血糖受损者的1.4倍(95%可信区间为0.753～2.508,P=0.29)和107倍(95%可信区间为1.021～2.80,P=0.028).转化为糖尿病者较未转化为精尿病者高血压、肥胖的比例增高,基线年龄、体重指数、腰围、腰臀比和2 h血精明显升高,随访结束时体重指数和收缩压较基线时增高.结论上海市浦东新区糖耐量受损合并空腹血糖受损者糖尿病转化率最高.多种代谢异常可促进糖调节受损人群向糖球病转化.
목적 탐토당조절수손인군발생당뇨병적위험성급기영향인소.방법 2002년6월지8월,채용추양분층횡단면현장조사방법우상해시포동신구사구중검출192례당조절수손자.2007년동기진행수방,관찰단순당내량수손、단순공복혈당수손、당내량수손합병공복혈당수손、당뇨병인군비례,변화.사용t검험、방차분석、잡방검험진행통계학분석.결과 5년중사망5례,존활적187례중79례발생당뇨병,당뇨병년전화솔위8.4%(79/187/5년).기선단순당내량수손자당뇨병년전화솔위8.2%(47/114/5년),기선단순공복혈당수손자정뇨병년전화솔위6.3%(12/38/5년),기선당내량수손합병공복혈당수손자당뇨병년전화솔위11.4%(20/35/5년).정상당내량년전화솔위6.3%(59/187/5년).단순당내량수손자화당내량수손합병공복혈당수손자발생당뇨병적풍험분별시단순공복혈당수손자적1.4배(95%가신구간위0.753～2.508,P=0.29)화107배(95%가신구간위1.021～2.80,P=0.028).전화위당뇨병자교미전화위정뇨병자고혈압、비반적비례증고,기선년령、체중지수、요위、요둔비화2 h혈정명현승고,수방결속시체중지수화수축압교기선시증고.결론 상해시포동신구당내량수손합병공복혈당수손자당뇨병전화솔최고.다충대사이상가촉진당조절수손인군향당구병전화.
Objective To investigate the outcome and risk factors of subjects with impaired glucose regulation (IGR). Methods A total of 192 IGR subjects from a cross-sectional survey in June to August 2002 were followed up for 5 years. Anthropometric measurement and 75 g oral glucose tolerance test were performed. The prevalence of isolated impaired fasting glucose (I-IFG), isolated impaired glucose tolerance (I-IGT), IFG + IGT, normal glucose tolerance (NGT) and diabetes mellitus (DM) was compared, t test,Chi-square test, and analysis of variance were used for data analysis. Results Five participants died during 5 years'follow up. Of the rest 187 subjects, 79 were found to develop DM. The annual incidence of DM and NGT was 8.4 % (79/187/5-y)and 6. 3% (59/187/5-y) , respectively. The annual incidence of DM was 8.2 % (47/114/5-y), 6. 3% (12/38/5-y) and 11.4% (20/35/5-y) for the subjects with I-IGT, I-IFG and IFG + IGT, respectively. The risk of DM was significantly higher in IFG + IGT subjects than I-IFT subjects. Compared with IGR subjects, those with new DM were characterized with hypertension, obesity,older age, and higher level of body mass index (BMI), waist circumference, waist-to-hip ratio and 2 h postprandial plasma glucose at baseline. BMI and systolic blood pressure during follow up were significantly higher than at baseline in subjects with new DM. Conclusions There might be a different course of I-IFG,I-IGT and IFG + IGT progressing to DM among community residents, and there is a higher conversion rate in IFG + IGT subjects. Various metabolic abnormalities can promote IGR progressing to DM.