CAJ | 학술논문

群体感应是细菌间依赖细胞密度的一种信息传递方式.细菌通过合成、分泌信号分子感知细菌群体密度,从而控制整个细菌群体行为.目前已在许多革兰阴性菌、革兰阳性菌和真菌中发现群体感应系统,对群体感应系统信号分子结构、信号传导通路进行大量研究后,发现其与细菌生物膜形成、生成分泌毒力因子密切相关.本文就以典型的铜绿假单胞菌、金黄色葡萄球菌、哈氏弧菌、白色念珠菌为例,对群体感应系统相关机制及研究进展予以综述.
군체감응시세균간의뢰세포밀도적일충신식전체방식.세균통과합성、분비신호분자감지세균군체밀도,종이공제정개세균군체행위.목전이재허다혁란음성균、혁란양성균화진균중발현군체감응계통,대군체감응계통신호분자결구、신호전도통로진행대량연구후,발현기여세균생물막형성、생성분비독력인자밀절상관.본문취이전형적동록가단포균、금황색포도구균、합씨호균、백색념주균위례,대군체감응계통상관궤제급연구진전여이종술.
Quorum sensing is a density-dependent cell-signaling m(cc)hanism,driven by secreted signaling molecules called autoinducer. Communication enables population of cells to synchronize gene expression.Thus,quorum sensing allows groups of bacteria to act in union by perception of bacterial population density.A number of quorum sensing systems have been found in gram-negative bacteria,grampositive bacteria and fungi,which are commonly associated with biofilm formation and virulence. This review focuses on the lasted mechanism of quorum sensing system based on typical pathogen,including Pseudomonas aeruginosa,Staphylococcus aureus,Vibrio harveyi and Candida albicans.