中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
2期
177-178
,共2页
中毒%百草枯%血必净%注射用甲泼尼龙琥珀酸钠
中毒%百草枯%血必淨%註射用甲潑尼龍琥珀痠鈉
중독%백초고%혈필정%주사용갑발니룡호박산납
Paraquat%Poisoning%Xuebijing%Methylprednisolone
目的 评价血必净联合大剂量注射用甲泼尼龙琥珀酸钠治疗急性百草枯中毒的效果.方法 选择我院急诊科2007年8月至2010年3月收治的重度急性百草枯中毒患者50例为研究对象,分为对照组24例和观察组26例.对照组为常规治疗；观察组在常规治疗基础上联合应用血必净注射液(100 ml静脉滴注,2次/d,连用7～10d)和静脉注射甲泼尼龙琥珀酸钠[15 mg/(kg·d),连用3d].动态监测、肝肾功能、血气分析等指标.结果 治疗2周后观察组酶学指标、血肌酐和血氧分压均明显改善,差异有统计学意义[ALT:(86±11 )U/L比(135±10) U/L；AST:(265±85) U/L比(543±130) U/L；总胆红素:(8±5)μmol/L比( 17±5)μmol/L; Cr:( 260±110)μmol/L比(532±185) pmol/L;动脉血氧分压:(77 ±13)mm Hg比(60±23)mm Hg(1 mm Hg =0.133 kPa)；P ＜0.05],观察组病死率低于对照组[34.6％ (9/26)比66.7％ (16/24)；P ＜0.05].结论 早期应用血必净联合大剂量注射甲泼尼龙琥珀酸钠可减轻百草枯对重要脏器的损害,降低百草枯中毒的病死率.
目的 評價血必淨聯閤大劑量註射用甲潑尼龍琥珀痠鈉治療急性百草枯中毒的效果.方法 選擇我院急診科2007年8月至2010年3月收治的重度急性百草枯中毒患者50例為研究對象,分為對照組24例和觀察組26例.對照組為常規治療；觀察組在常規治療基礎上聯閤應用血必淨註射液(100 ml靜脈滴註,2次/d,連用7～10d)和靜脈註射甲潑尼龍琥珀痠鈉[15 mg/(kg·d),連用3d].動態鑑測、肝腎功能、血氣分析等指標.結果 治療2週後觀察組酶學指標、血肌酐和血氧分壓均明顯改善,差異有統計學意義[ALT:(86±11 )U/L比(135±10) U/L；AST:(265±85) U/L比(543±130) U/L；總膽紅素:(8±5)μmol/L比( 17±5)μmol/L; Cr:( 260±110)μmol/L比(532±185) pmol/L;動脈血氧分壓:(77 ±13)mm Hg比(60±23)mm Hg(1 mm Hg =0.133 kPa)；P ＜0.05],觀察組病死率低于對照組[34.6％ (9/26)比66.7％ (16/24)；P ＜0.05].結論 早期應用血必淨聯閤大劑量註射甲潑尼龍琥珀痠鈉可減輕百草枯對重要髒器的損害,降低百草枯中毒的病死率.
목적 평개혈필정연합대제량주사용갑발니룡호박산납치료급성백초고중독적효과.방법 선택아원급진과2007년8월지2010년3월수치적중도급성백초고중독환자50례위연구대상,분위대조조24례화관찰조26례.대조조위상규치료；관찰조재상규치료기출상연합응용혈필정주사액(100 ml정맥적주,2차/d,련용7～10d)화정맥주사갑발니룡호박산납[15 mg/(kg·d),련용3d].동태감측、간신공능、혈기분석등지표.결과 치료2주후관찰조매학지표、혈기항화혈양분압균명현개선,차이유통계학의의[ALT:(86±11 )U/L비(135±10) U/L；AST:(265±85) U/L비(543±130) U/L；총담홍소:(8±5)μmol/L비( 17±5)μmol/L; Cr:( 260±110)μmol/L비(532±185) pmol/L;동맥혈양분압:(77 ±13)mm Hg비(60±23)mm Hg(1 mm Hg =0.133 kPa)；P ＜0.05],관찰조병사솔저우대조조[34.6％ (9/26)비66.7％ (16/24)；P ＜0.05].결론 조기응용혈필정연합대제량주사갑발니룡호박산납가감경백초고대중요장기적손해,강저백초고중독적병사솔.
Objective To evaluate the effects of Xuebijing combined with high doses of methylprednisolone on the treatment of acute paraquat poisoning.Methods Totally 50 patients with acute paraquat poisoning were admitted to our hospital from August 2007 to March 2010 and were divided into test group and control group.Patients in control group were treated with routine therapy.Test group accepted Xuebijing combined with high doses of methylprednisolone which substituted dexamethasone on the basis of control group.Results The oxygen pressure,zymologic indexes and blood creatinine in test group were significantly different from those in control group [ ALT:( 86 ±11 ) U/L vs ( 135 ± 10 ) U/L; AST:( 265 ± 85 ) U/L vs (543 ± 130) U/L; TBil:( 8 ± 5 ) μmol/L vs ( 17 ± 5 ) μmol/L;Cr:(260 ± 110) μmol/L vs (532 ± 185) μmol/L;PaO2:(77 ± 13) vs (60 ± 23) ;P ＜ 0.05 ].The mortality of test group was lower than that of control group [ 34.6％ (9/26) vs 66.7％ (16/24) ; P ＜ 0.05 ].Conclusion At the early stage,Xuebijing combined with high doses of methylprednisolone can protect major organs from paraquat injury and reduce the mortality of paraquat poisoning.
