中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2011年
8期
606-607
,共2页
缪荣明%张雪涛%严于兰%何恩奇%郭平%张颖轶%赵道昆%杨志刚%陈洁%姚明莺%赵锐%房中华%姚雍铭
繆榮明%張雪濤%嚴于蘭%何恩奇%郭平%張穎軼%趙道昆%楊誌剛%陳潔%姚明鶯%趙銳%房中華%姚雍銘
무영명%장설도%엄우란%하은기%곽평%장영질%조도곤%양지강%진길%요명앵%조예%방중화%요옹명
矽肺%转化生长因子-β1%肿瘤坏死因子-α
矽肺%轉化生長因子-β1%腫瘤壞死因子-α
석폐%전화생장인자-β1%종류배사인자-α
silicosis%transforming growth factor-β1(TGF-β1)%tumor necrosis factor-α(TNF-α)
目的 观察矽尘接触者和矽肺患者及观察对象血清转化生长因子-β1(TGF-β1)和肿瘤坏死因子-α(TNF-α)水平,探讨TGF-β1、TNF-α在矽肺发生发展中的作用.方法 选择100名不接触粉尘的对照人群(对照组),200名接触矽尘1年以上的接尘工人(接尘组),32名矽尘作业观察对象(0+)(观察对照组)及130例矽肺患者(矽肺组),采用ELISA法检测其血清TGF-β1和TNF-α水平.结果 与对照组[(6.90±2.24)pg/ml]比较,接尘组、观察对象组和矽肺组TNF-α水平[(47.86±16.52)、(109.11±31.08)、(216.35±51.03)pg/ml]明显升高,差异有统计学意义(P＜0.01);与接尘组比较,观察对象组和矽肺组TNF-α水平明显升高,差异有统计学意义(P＜0.05,P＜0.01).与对照组[(23.28±12.24)pg/ml]和接尘组[(29.31±14.52)pg/ml]比较,观察对象组和矽肺组TGF-β1水平[(46.16±17.35)、(58.36±31.94)pg/ml]明显升高,差异有统计学意义(P＜0.05,P＜0.01).结论 TGF-β1和TNF-α在矽肺发生发展中有重要作用,检测外周血TGF-β1和TNF-α水平可应用于职业健康监护及矽肺的早期诊断.
目的 觀察矽塵接觸者和矽肺患者及觀察對象血清轉化生長因子-β1(TGF-β1)和腫瘤壞死因子-α(TNF-α)水平,探討TGF-β1、TNF-α在矽肺髮生髮展中的作用.方法 選擇100名不接觸粉塵的對照人群(對照組),200名接觸矽塵1年以上的接塵工人(接塵組),32名矽塵作業觀察對象(0+)(觀察對照組)及130例矽肺患者(矽肺組),採用ELISA法檢測其血清TGF-β1和TNF-α水平.結果 與對照組[(6.90±2.24)pg/ml]比較,接塵組、觀察對象組和矽肺組TNF-α水平[(47.86±16.52)、(109.11±31.08)、(216.35±51.03)pg/ml]明顯升高,差異有統計學意義(P＜0.01);與接塵組比較,觀察對象組和矽肺組TNF-α水平明顯升高,差異有統計學意義(P＜0.05,P＜0.01).與對照組[(23.28±12.24)pg/ml]和接塵組[(29.31±14.52)pg/ml]比較,觀察對象組和矽肺組TGF-β1水平[(46.16±17.35)、(58.36±31.94)pg/ml]明顯升高,差異有統計學意義(P＜0.05,P＜0.01).結論 TGF-β1和TNF-α在矽肺髮生髮展中有重要作用,檢測外週血TGF-β1和TNF-α水平可應用于職業健康鑑護及矽肺的早期診斷.
목적 관찰석진접촉자화석폐환자급관찰대상혈청전화생장인자-β1(TGF-β1)화종류배사인자-α(TNF-α)수평,탐토TGF-β1、TNF-α재석폐발생발전중적작용.방법 선택100명불접촉분진적대조인군(대조조),200명접촉석진1년이상적접진공인(접진조),32명석진작업관찰대상(0+)(관찰대조조)급130례석폐환자(석폐조),채용ELISA법검측기혈청TGF-β1화TNF-α수평.결과 여대조조[(6.90±2.24)pg/ml]비교,접진조、관찰대상조화석폐조TNF-α수평[(47.86±16.52)、(109.11±31.08)、(216.35±51.03)pg/ml]명현승고,차이유통계학의의(P＜0.01);여접진조비교,관찰대상조화석폐조TNF-α수평명현승고,차이유통계학의의(P＜0.05,P＜0.01).여대조조[(23.28±12.24)pg/ml]화접진조[(29.31±14.52)pg/ml]비교,관찰대상조화석폐조TGF-β1수평[(46.16±17.35)、(58.36±31.94)pg/ml]명현승고,차이유통계학의의(P＜0.05,P＜0.01).결론 TGF-β1화TNF-α재석폐발생발전중유중요작용,검측외주혈TGF-β1화TNF-α수평가응용우직업건강감호급석폐적조기진단.
Objective To observe serum TGF-β1 and TNF-α in silicosis patients and workers exposed to silica dust to study the role of TGF-β1 and TNF-α in the development of silicosis.Methods One hundred non-exposed workers were selected as control group, 200 workers exposed to silica dust for more than 1 year as exposed group, 32 suspected silicosis patients (originally diagnosed as 0+) as observing group, 130 silicosis patients were as silicosis group.Serum TGF-β1 and TNF-α in each group were determined with ELISA.Results Serum TNF-α in exposed group[(47.86± 16.52) pg/ml], observing group[( 109.1 1±31.08) pg/ml], silicosis group [(216.35±51.03) pg/ml] were significantly higher than that in control group [(6.90±2.24) pg/ml] (P＜0.01); Silicosis group and observing group were also higher than exposed group ( P＜0.01, P＜0.05 ).Compared with control group [(23.28± 12.24) pg/ml] and exposed group [( 29.31 ± 14.52) pg/ml], serum TGF-β1 in silicosis group was much higher (P＜0.01).Conclusion TGF-β1 and TNF-α were essential in the development of silicosis, so the detection of TGF-β1 and TNF-α in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.
