中国组织工程研究与临床康复
中國組織工程研究與臨床康複
중국조직공정연구여림상강복
JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH
2008年
50期
9997-10000
,共4页
王文志%杨定焯%蒋建军%吴涛%程晓光%周琦%卓铁军%张华俦%项静%王洪复%区品中%刘建立%徐苓%黄公怡%黄琪仁%HS Barden%LS Weynand%KG Fqukner%孟迅吾
王文誌%楊定焯%蔣建軍%吳濤%程曉光%週琦%卓鐵軍%張華儔%項靜%王洪複%區品中%劉建立%徐苓%黃公怡%黃琪仁%HS Barden%LS Weynand%KG Fqukner%孟迅吾
왕문지%양정작%장건군%오도%정효광%주기%탁철군%장화주%항정%왕홍복%구품중%류건립%서령%황공이%황기인%HS Barden%LS Weynand%KG Fqukner%맹신오
青年人群%骨密度%标准差%骨质疏松%检出率%组织构建
青年人群%骨密度%標準差%骨質疏鬆%檢齣率%組織構建
청년인군%골밀도%표준차%골질소송%검출솔%조직구건
背景: 不同地区骨峰值和标准差不同,对骨质疏松诊断率有较大影响.探讨建立一完整数据库为中国人骨质疏松诊断准确性提供依据.目的: 探讨青年人腰椎骨密度和标准差正常参考值影响骨质疏松症检出率的程度.设计、时间及地点: 调查分析,于1997-01/1999-12分别在北京、上海、广州、南京、嘉兴和成都市完成.对象:采用前瞻性及回顾性方法对全国6个中心骨密度参考数据库中11 418人进行调查统计分析;男3 666人,女7 752人:年龄20岁～90岁;分别来自北京(2 385人)、广州(1 178人)、上海(1 404人)、南京(2 938人)、成都(1 425人)、嘉兴(2 088人),受试者来源于社区调查、健康体检和健康志愿者.方法: 用GE-Lunar公司的DXA仪测量骨密度,调查全国6个中心11 418人L2～L4腰椎后前位和髋部骨密度,建立了骨密度参考数据库.6个中心的仪器内部精度0.3%～0.7%,仪器间的精度1.1%.主要观察指标: ①6个中心不同年龄组腰椎骨密度分布.②青年人群骨密度及其标准差值对骨质疏松症检出率的影响.结果: 中国汉族女件以腰椎进行骨质疏松症诊断的青年人群的骨密度和标准差值,6个中心,最大差值分别为0.098 g/cm2和0.027 g/cm2.用6个中心及总体各自的青年人平均骨密度和标准差值为参考标准,对同-人群计算T-score和获得的骨质疏松症检出率不相同:发现肯年人平均骨密度每变化0.01 g/cm2,则骨质疏松症检出率变化1.6%(呈正相关),其标准差值每变化0.01 g/cm2,则骨质疏松症检出率变化4%(呈负相关).结论: 青年人平均骨密度和标准差值不同引起骨质疏松症检出率也不相同.为了让不同中心的骨质疏松症检出率有可比性,建议同一个类型的骨密度仪,同一个种族同一个地区用一个设计较完善大样本的参考数据库,以其青年人正常参考值计算T-score.
揹景: 不同地區骨峰值和標準差不同,對骨質疏鬆診斷率有較大影響.探討建立一完整數據庫為中國人骨質疏鬆診斷準確性提供依據.目的: 探討青年人腰椎骨密度和標準差正常參攷值影響骨質疏鬆癥檢齣率的程度.設計、時間及地點: 調查分析,于1997-01/1999-12分彆在北京、上海、廣州、南京、嘉興和成都市完成.對象:採用前瞻性及迴顧性方法對全國6箇中心骨密度參攷數據庫中11 418人進行調查統計分析;男3 666人,女7 752人:年齡20歲～90歲;分彆來自北京(2 385人)、廣州(1 178人)、上海(1 404人)、南京(2 938人)、成都(1 425人)、嘉興(2 088人),受試者來源于社區調查、健康體檢和健康誌願者.方法: 用GE-Lunar公司的DXA儀測量骨密度,調查全國6箇中心11 418人L2～L4腰椎後前位和髖部骨密度,建立瞭骨密度參攷數據庫.6箇中心的儀器內部精度0.3%～0.7%,儀器間的精度1.1%.主要觀察指標: ①6箇中心不同年齡組腰椎骨密度分佈.②青年人群骨密度及其標準差值對骨質疏鬆癥檢齣率的影響.結果: 中國漢族女件以腰椎進行骨質疏鬆癥診斷的青年人群的骨密度和標準差值,6箇中心,最大差值分彆為0.098 g/cm2和0.027 g/cm2.用6箇中心及總體各自的青年人平均骨密度和標準差值為參攷標準,對同-人群計算T-score和穫得的骨質疏鬆癥檢齣率不相同:髮現肯年人平均骨密度每變化0.01 g/cm2,則骨質疏鬆癥檢齣率變化1.6%(呈正相關),其標準差值每變化0.01 g/cm2,則骨質疏鬆癥檢齣率變化4%(呈負相關).結論: 青年人平均骨密度和標準差值不同引起骨質疏鬆癥檢齣率也不相同.為瞭讓不同中心的骨質疏鬆癥檢齣率有可比性,建議同一箇類型的骨密度儀,同一箇種族同一箇地區用一箇設計較完善大樣本的參攷數據庫,以其青年人正常參攷值計算T-score.
배경: 불동지구골봉치화표준차불동,대골질소송진단솔유교대영향.탐토건립일완정수거고위중국인골질소송진단준학성제공의거.목적: 탐토청년인요추골밀도화표준차정상삼고치영향골질소송증검출솔적정도.설계、시간급지점: 조사분석,우1997-01/1999-12분별재북경、상해、엄주、남경、가흥화성도시완성.대상:채용전첨성급회고성방법대전국6개중심골밀도삼고수거고중11 418인진행조사통계분석;남3 666인,녀7 752인:년령20세～90세;분별래자북경(2 385인)、엄주(1 178인)、상해(1 404인)、남경(2 938인)、성도(1 425인)、가흥(2 088인),수시자래원우사구조사、건강체검화건강지원자.방법: 용GE-Lunar공사적DXA의측량골밀도,조사전국6개중심11 418인L2～L4요추후전위화관부골밀도,건립료골밀도삼고수거고.6개중심적의기내부정도0.3%～0.7%,의기간적정도1.1%.주요관찰지표: ①6개중심불동년령조요추골밀도분포.②청년인군골밀도급기표준차치대골질소송증검출솔적영향.결과: 중국한족녀건이요추진행골질소송증진단적청년인군적골밀도화표준차치,6개중심,최대차치분별위0.098 g/cm2화0.027 g/cm2.용6개중심급총체각자적청년인평균골밀도화표준차치위삼고표준,대동-인군계산T-score화획득적골질소송증검출솔불상동:발현긍년인평균골밀도매변화0.01 g/cm2,칙골질소송증검출솔변화1.6%(정정상관),기표준차치매변화0.01 g/cm2,칙골질소송증검출솔변화4%(정부상관).결론: 청년인평균골밀도화표준차치불동인기골질소송증검출솔야불상동.위료양불동중심적골질소송증검출솔유가비성,건의동일개류형적골밀도의,동일개충족동일개지구용일개설계교완선대양본적삼고수거고,이기청년인정상삼고치계산T-score.
BACKGROUND: Peak bone mass and standard deviation (SD) in different regions are varied, which have great influence on diagnosis of osteoporosis. To establish a complete database can provide accurate evidence for osteoporosis diagnosis. OBJECTIVE: To investigate the influence of bone mineral densities (BMD) and their SD of young people on the detective rate of osteoporosis in general population. DESIGN, TIME AND SETTING: Investigation analysis was performed at Beijing, Shanghai, Guangzhou, Nanjing, Jiaxing and Chengdu between January 1997 and December 1999. PARTICIPANTS: 11418 subjects from related 6 centers of BMD reference database in China were investigated and analyzed using prospective and retrospective methods, including 3 666 males, and 7 752 females aged 20-90 years. Of them, 2385 were from Beijing, 1178 from Guangzhou, 1404 from Shanghai, 2938 from Nanjing, 1425 from Chengdu, and 2088 from Jiaxing. The subjects were selected from community investigation, physical examination volunteers. METHODS: BMD of the lumbar spine (L2-4) and the hip in 11, 418 subjects from the related 6 centers in China was measured with GE-Lunar dual energy X-ray absorptiometry (DXA) and the BMD reference database was established. The accuracy rate of the inner machine was 0.3%-0.7%, and the accuracy of different machines averaged 1.1%. MAIN OUTCOME MEASURES: Lumbar BMD distribution of different age groups from 6 centers; influence of young people's BMD and its SD on detective rate of osteoporosis. RESULTS: Different BMD and SD were found in the individual subject from 6 centers, and the maximum differences were 0.098 g/cm2 and 0.027 g/cm2. With mean BMD and SD of the individuals from 6 centers as references, different T-scores and the detective rates of osteoporosis derived from the T-scores were found in the same group. The detective rate increased by 1.6% when BMD of the young people increased by 0.01 g/cm2 (positive correlation), but the detective rate decreased by 4% when SD increased by 0.01g/cm2 (negative correlation). CONCLUSION: Changes in BMD and SD of the young people can influence the detective rate of osteoporosis. To achieve comparability for the detective rate of osteoporosis in different centers, the specific reference database should be established for the same race, the same area, and the same bone densitometry machine. The T-score should be determined with the normal BMD and SD of the young, people as the reference database.
