CAJ | 학술논문

目的利用脑功能磁共振成像(fMRI)技术研究健康成人不同吞咽任务时激活脑区的特点.方法 8名健康志愿者参与实验性自主和反射性吞咽任务的fMRI研究.采用SPM2软件对功能成像数据进行处理及图像显示.配对t检验用于比较2种吞咽任务激活脑区的容积及信号值大小.结果自主吞咽任务激活脑区有双侧初级感觉运动皮质、运动前区、前扣带回等.反射性吞咽任务相关脑区有双侧初级感觉皮层、双侧额盖、双侧顶后区.自主性吞咽激活双侧半球容积(体素)分别为1213±110(左)、1969±133(右).反射吞咽激活双侧半球容积(体素)分别为488±45(左)、398±35(右).自主性咽水双侧感觉运动区信号增加值分别为4.4±0.4(左)、4.1±0.2(右);双侧岛叶容积为1.2±0.5(左)、1.5±0.6(右).反射性咽水双侧感觉运动区信号增加值分别为2.6±0.3(左)、2.5±1.2(右);双侧岛叶信号增加值为0.6±0.4(左)、0.2±0.1(右).自主吞咽激活双侧半球容积、感觉运动区及岛叶信号值均大于反射性吞咽(均为P<0.05).两种吞咽任务的偏侧性指数(LI)值分别为(-16±9)%和(11±5)%.结论自主吞咽任务激活脑区数量及容积大于反射性吞咽任务.两种吞咽任务激活脑区的不同与自主吞咽过程中计划、发动、情感等多种高级脑活动有关.
목적 이용뇌공능자공진성상(fMRI)기술연구건강성인불동탄인임무시격활뇌구적특점.방법 8명건강지원자삼여실험성자주화반사성탄인임무적fMRI연구.채용SPM2연건대공능성상수거진행처리급도상현시.배대t검험용우비교2충탄인임무격활뇌구적용적급신호치대소.결과 자주탄인임무격활뇌구유쌍측초급감각운동피질、운동전구、전구대회등.반사성탄인임무상관뇌구유쌍측초급감각피층、쌍측액개、쌍측정후구.자주성탄인격활쌍측반구용적(체소)분별위1213±110(좌)、1969±133(우).반사탄인격활쌍측반구용적(체소)분별위488±45(좌)、398±35(우).자주성인수쌍측감각운동구신호증가치분별위4.4±0.4(좌)、4.1±0.2(우);쌍측도협용적위1.2±0.5(좌)、1.5±0.6(우).반사성인수쌍측감각운동구신호증가치분별위2.6±0.3(좌)、2.5±1.2(우);쌍측도협신호증가치위0.6±0.4(좌)、0.2±0.1(우).자주탄인격활쌍측반구용적、감각운동구급도협신호치균대우반사성탄인(균위P<0.05).량충탄인임무적편측성지수(LI)치분별위(-16±9)%화(11±5)%.결론 자주탄인임무격활뇌구수량급용적대우반사성탄인임무.량충탄인임무격활뇌구적불동여자주탄인과정중계화、발동、정감등다충고급뇌활동유관.
Objective To investigate the swallow-related brain areas in normal adults with different experimental swallow tasks using founctional MRI (fMRI). Methods Eight healthy volunteers received volitional and reflexive water swallowing during fMRI studies. SPM2 software was used to postprocess functional data and display activated brain mapping. Paired t-test was used to compare the activated brain volume and increased signal of each hemisphere in two swallowing tasks. Results Bilateral primary sensorimotor cortex, premotor cortex, anterior cingnlated gyrus, insular, prefrontal area, posterior parietal lobe, temporal gyms , basal ganglion and cerebellum were detected in volitional water swallowing. However, only few brain areas such as bilateral primary sensorimotor cortex, posterior parietal lobe, frontal opercnlum were activated in reflexive water swallowing task. Volitional swallowing tasks activated much more brain volumes [1213±110 (left) and 1969±133 (right) vs 488±45 (left) and 398±35 (right), in pixels] and increase in signals [4.4±0.4 (left) and 4.1±0.2 (right) vs 2.6±0.3 (left) and 2.5±1.2 (right) at sensorimotor areas, 1.2±0.5 (left) and 1.5±0.6 (right) vs 0.6±0.4 (left) and 0.2±0.1 (right) at insular lobes] than those in reflexive tasks. Different lateralization in activation brain area was observed in swallowing tasks. Lateral index was ( - 16 ±9) % and ( 11 ±5 ) % respectively in volitional and reflexive water swallowing tasks. Conclusions Volitional swallowing task activates much more brain regions and brain volumes as compared to reflexive tasks. The different activated regions between volitional and reflexive swallowing tasks maybe relate to brain activities such as intent, planning, urge and possibly passion during volitional swallowing.