CAJ | 학술논문

奈达铂、奥沙利铂等新型铂类抗肿瘤药物在临床上广泛应用,其具有抗癌谱广、活性强、不良反应低、与顺铂无交叉耐药性等特点.此外,尚处于临床研究中的亲脂性铂配合物、多核铂配合物等新型铂类化合物,也显示出提高疗效、降低不良反应的优势.目前的研究主要是通过改良顺铂、卡铂的结构和探索结构全新的铂类化合物,以达到提高患者生活质量、延长生存时间的目的 .铂类化合物在细胞毒药物中仍然占有重要的地位和良好的应用前景.
내체박、오사리박등신형박류항종류약물재림상상엄범응용,기구유항암보엄、활성강、불량반응저、여순박무교차내약성등특점.차외,상처우림상연구중적친지성박배합물、다핵박배합물등신형박류화합물,야현시출제고료효、강저불량반응적우세.목전적연구주요시통과개량순박、잡박적결구화탐색결구전신적박류화합물,이체도제고환자생활질량、연장생존시간적목적 .박류화합물재세포독약물중잉연점유중요적지위화량호적응용전경.
Nedaplatin and oxaliplatin are widely used in clinic as new antineoplastic agents against a broad spectrum of solid tumors, which are characterized by broader anticancer spectrum, higher activity and less toxicity, especially no cross resistance with cisplatin. In addition, the lipophilic platinum compound, the muhinuclear platinum compound and others are being still clinically tested, which also show the advantages of high efficacy and low toxicity. Current researches are mainly focus on reforming the structure of cisplatin and carboplatin, and exploring platinum compounds with totally new structure to improve quality of life and prolon-ging survival time of patients. Platinum compounds still have exceedingly vital position and satisfactory applica-tion perspective in cytotoxic drugs.