中华眼外伤职业眼病杂志
中華眼外傷職業眼病雜誌
중화안외상직업안병잡지
CHINESE JOURNAL OF OCULAR TRAUMA AND OCCUPATIONAL EYE DISEASE
2011年
5期
321-323
,共3页
Avastin%角膜血管新生%兔
Avastin%角膜血管新生%兔
Avastin%각막혈관신생%토
Avastin%corneal neovascularization%rabbit
目的 探讨Avastin对角膜新生血管(NV)的抑制作用.方法 日本大耳白兔20只,以角膜缝线法制作角膜新生血管模型,观察4周.在角膜缝线1周后,实验组以浓度为4mg/mL的Avastin溶液滴眼,对照组以注射用水滴眼,均为每日2次,共28 d.记录角膜新生血管出现的时间、生长的长度和数量.结果 两组角膜新生血管的出现时间分别为(3.43±0.53) d和(3.14±0.69)d (P>0.05);在缝线后 14d、21d、28d,实验组角膜新生血管的面积均明显小于对照组(P<0.05).且实验组角膜新生血管在用药后明显变细.两组角膜荧光素染色在观察期间均未发现明显着色.结论 Avastin滴眼能够有效抑制角膜新生血管的生长,并能在一定程度上使已有的新生血管消退,且未发现明显的毒副作用.
目的 探討Avastin對角膜新生血管(NV)的抑製作用.方法 日本大耳白兔20隻,以角膜縫線法製作角膜新生血管模型,觀察4週.在角膜縫線1週後,實驗組以濃度為4mg/mL的Avastin溶液滴眼,對照組以註射用水滴眼,均為每日2次,共28 d.記錄角膜新生血管齣現的時間、生長的長度和數量.結果 兩組角膜新生血管的齣現時間分彆為(3.43±0.53) d和(3.14±0.69)d (P>0.05);在縫線後 14d、21d、28d,實驗組角膜新生血管的麵積均明顯小于對照組(P<0.05).且實驗組角膜新生血管在用藥後明顯變細.兩組角膜熒光素染色在觀察期間均未髮現明顯著色.結論 Avastin滴眼能夠有效抑製角膜新生血管的生長,併能在一定程度上使已有的新生血管消退,且未髮現明顯的毒副作用.
목적 탐토Avastin대각막신생혈관(NV)적억제작용.방법 일본대이백토20지,이각막봉선법제작각막신생혈관모형,관찰4주.재각막봉선1주후,실험조이농도위4mg/mL적Avastin용액적안,대조조이주사용수적안,균위매일2차,공28 d.기록각막신생혈관출현적시간、생장적장도화수량.결과 량조각막신생혈관적출현시간분별위(3.43±0.53) d화(3.14±0.69)d (P>0.05);재봉선후 14d、21d、28d,실험조각막신생혈관적면적균명현소우대조조(P<0.05).차실험조각막신생혈관재용약후명현변세.량조각막형광소염색재관찰기간균미발현명현착색.결론 Avastin적안능구유효억제각막신생혈관적생장,병능재일정정도상사이유적신생혈관소퇴,차미발현명현적독부작용.
Objective To evaluate the effect of Aavastin to inhibit experimental corneal neovascularization. Methods Twenty rabbits were sutured on the superior cornea. Animals were randomly divided into 2 groups. After 7 days, 10 eyes in the treatment group were given Aavastin drops(4 rog/mi) twice daily, whereas 10 eyes in the control group received placebo (normal saline drops twice daily). The occurrence and developement of CNV was observed on the 3, 7, 14, 21,28 days after suturing by slit-lamp microscope, and the area of CNV was calculated. Fluorescein staining was detected for the integrity of corneal epithelium. Results The occurrence of CNV in group 1 was (3.43±0.53)d and group 2 (3.14±0.69)d. No significant difference in the occurrence time of CNV was found between group 1 and group 2. The CNV areas of group 1 were significantly smaller than that of group 2 at every time poin(P<0.05). The diameter of CNV was significantly smaller after Avastin treatment. Conclusion Avastin can inhibit and restrain corneal neovascularization at some degree without significant side effects.
