目的 应用功能磁共振成像(fMRI)技术探讨前瞻记忆(PM)的脑区激活及神经机制.方法 共有15名健康志愿者入组,以基于事件前瞻记忆(双任务范式,包括进行中任务和前瞻记忆任务)作为刺激任务,应用GRE-EPI序列采集血氧水平依赖性(BOLD) fMRI信号.应用SPM8软件对图像数据进行预处理和统计分析.结果 (1)相对于对照任务,进行中任务主要激活双侧前额叶额极(x,y,z =6/-2,54/42,- 8/- 12,t=3.71),右侧的体感联合区(x,y,z=14,- 62,64,t=4.64)、颞上回(x,y,z=42,- 46,16,t=3.95)及旁中央小叶(x,y,z=10,- 22,76,t=4.01),差异具有统计学意义(P＜0.01).(2)前瞻记忆任务主要激活双侧前额叶额极(x,y,z=-2/6,42/54,- 12/- 12,=3.28)及旁中央小叶(x,y,z=- 30/10,-22/-22,72/76,t=4.25),左侧中央后回(x,y,z=-38,-46,64,t=3.13)及枕叶(x,y,z=-30,-70,0,=3.97),差异具有统计学意义(P＜0.01).结论 前额叶额极(布罗德曼10区,BA10区)是前瞻记忆的关键激活脑区,BA10区内侧可能参与对外部线索的监控,支持前瞻记忆的BA10门控假说.
目的 應用功能磁共振成像(fMRI)技術探討前瞻記憶(PM)的腦區激活及神經機製.方法 共有15名健康誌願者入組,以基于事件前瞻記憶(雙任務範式,包括進行中任務和前瞻記憶任務)作為刺激任務,應用GRE-EPI序列採集血氧水平依賴性(BOLD) fMRI信號.應用SPM8軟件對圖像數據進行預處理和統計分析.結果 (1)相對于對照任務,進行中任務主要激活雙側前額葉額極(x,y,z =6/-2,54/42,- 8/- 12,t=3.71),右側的體感聯閤區(x,y,z=14,- 62,64,t=4.64)、顳上迴(x,y,z=42,- 46,16,t=3.95)及徬中央小葉(x,y,z=10,- 22,76,t=4.01),差異具有統計學意義(P＜0.01).(2)前瞻記憶任務主要激活雙側前額葉額極(x,y,z=-2/6,42/54,- 12/- 12,=3.28)及徬中央小葉(x,y,z=- 30/10,-22/-22,72/76,t=4.25),左側中央後迴(x,y,z=-38,-46,64,t=3.13)及枕葉(x,y,z=-30,-70,0,=3.97),差異具有統計學意義(P＜0.01).結論 前額葉額極(佈囉德曼10區,BA10區)是前瞻記憶的關鍵激活腦區,BA10區內側可能參與對外部線索的鑑控,支持前瞻記憶的BA10門控假說.
목적 응용공능자공진성상(fMRI)기술탐토전첨기억(PM)적뇌구격활급신경궤제.방법 공유15명건강지원자입조,이기우사건전첨기억(쌍임무범식,포괄진행중임무화전첨기억임무)작위자격임무,응용GRE-EPI서렬채집혈양수평의뢰성(BOLD) fMRI신호.응용SPM8연건대도상수거진행예처리화통계분석.결과 (1)상대우대조임무,진행중임무주요격활쌍측전액협액겁(x,y,z =6/-2,54/42,- 8/- 12,t=3.71),우측적체감연합구(x,y,z=14,- 62,64,t=4.64)、섭상회(x,y,z=42,- 46,16,t=3.95)급방중앙소협(x,y,z=10,- 22,76,t=4.01),차이구유통계학의의(P＜0.01).(2)전첨기억임무주요격활쌍측전액협액겁(x,y,z=-2/6,42/54,- 12/- 12,=3.28)급방중앙소협(x,y,z=- 30/10,-22/-22,72/76,t=4.25),좌측중앙후회(x,y,z=-38,-46,64,t=3.13)급침협(x,y,z=-30,-70,0,=3.97),차이구유통계학의의(P＜0.01).결론 전액협액겁(포라덕만10구,BA10구)시전첨기억적관건격활뇌구,BA10구내측가능삼여대외부선색적감공,지지전첨기억적BA10문공가설.
Objective To investigate the neural mechanism of prospective memory(PM) using functional magnetic resonance imaging (fMRI).Methods Fifteen healthy volunteers were enrolled,and all subjects were scanned with fMRI while performing the event-based PM tasks (double-task paradigm,including the ongoing task and PM task).And the image data were preprocessed and analyzed by using SPM8 software.Results ( 1 ) Compared to the control task,bilateral rostral prefrontal cortex ( x,y,z =6/- 2,54/42,- 8/- 12,t =3.71 ),right somatosensory association area ( x,y,z =14,- 62,64,t =4.64 ),superior temporal gyrus ( x,y,z =42,- 46,16,t =3.95 ) and right paracentral lobule (x,y,z =10,-22,76,t =4.01 ) were activated significantly by the ongoing task (P ＜ 0.001 ).(2) Bilateral rostral prefrontal cortex ( x,y,z =- 2/6,42/54,- 12/- 12,t =3.28) and paracentral lobule (x,y,z =- 30/10,- 22/- 22,72/76,t =4.25 ),left postcentral gyrus ( x,y,z =- 38,- 46,64,t=3.13) and middle occipital gyrus ( x,y,z =- 30,- 70,0,t =3.97 ) were activated significantly by the PM task (P ＜ 0.001 ).Conclusion Rostral prefrontal cortex (BA 10 area) is the major area of prospective memory,and medial BA10 area may be involved in the monitoring of external cues.The present study supports the gateway hypotheses of prospective memory.
