中国抗生素杂志
中國抗生素雜誌
중국항생소잡지
CHINESE JOURNAL OF ANTIBIOTICS
2010年
1期
59-64
,共6页
董一山%黄文祥%章成%罗涛%朱卫民%李崇智%郑行萍
董一山%黃文祥%章成%囉濤%硃衛民%李崇智%鄭行萍
동일산%황문상%장성%라도%주위민%리숭지%정행평
肺炎链球菌%耐药性%血清型%最低抑菌浓度
肺炎鏈毬菌%耐藥性%血清型%最低抑菌濃度
폐염련구균%내약성%혈청형%최저억균농도
Streptococcus Pneumonia%Serotype%Resistance%Minimal inhibition concentrations
目的 了解重庆地区的临床分离肺炎链球菌的常见血清型分布及其耐药情况,并对常见血清型菌株和其它血清型菌株的耐药情况进行比较.方法 应用荚膜肿胀实验检测2006年1月～2008年8月临床分离的143株肺炎链球菌的血清型,并采用琼脂稀释法检测常用抗菌药物的最低抑菌浓度(MIC).结果 总的常见血清型为型/群为19群、6群、5型、10群、15群,但从成人分离的菌株常见血清型为19群、10群、5型、33群,儿童则以19群、6群、15群和23群血清型为主.143株菌对阿奇霉素、克林霉素、左氧氟沙星、头孢唑林、青霉素的耐药率(耐药+中介)分别是97.9%、95.8%、4.2%、0.7%、58.1%,对于青霉素的敏感率是42%.常见血清型肺炎链球菌对5种抗菌素的耐药率(耐药+中介)分别是:97.7%、97.7%、1.1%、3.4%、72.4%;其它血清型菌的耐药率分别是:98.2%、92.9%、5.4%、0、35.7%.;仅青霉素耐药率有统计学意义差别.结论 重庆地区临床分离的肺炎链球菌的常见血清型与其它地区报道有一定差别.对左氧氟沙星、头孢唑林耐药率低,对青霉素的耐药率与国内报道接近,但对于阿奇霉素及克林霉素的耐药率高.常见血清型肺炎链球菌对青霉素的耐药率明显高于其它血清型.
目的 瞭解重慶地區的臨床分離肺炎鏈毬菌的常見血清型分佈及其耐藥情況,併對常見血清型菌株和其它血清型菌株的耐藥情況進行比較.方法 應用莢膜腫脹實驗檢測2006年1月～2008年8月臨床分離的143株肺炎鏈毬菌的血清型,併採用瓊脂稀釋法檢測常用抗菌藥物的最低抑菌濃度(MIC).結果 總的常見血清型為型/群為19群、6群、5型、10群、15群,但從成人分離的菌株常見血清型為19群、10群、5型、33群,兒童則以19群、6群、15群和23群血清型為主.143株菌對阿奇黴素、剋林黴素、左氧氟沙星、頭孢唑林、青黴素的耐藥率(耐藥+中介)分彆是97.9%、95.8%、4.2%、0.7%、58.1%,對于青黴素的敏感率是42%.常見血清型肺炎鏈毬菌對5種抗菌素的耐藥率(耐藥+中介)分彆是:97.7%、97.7%、1.1%、3.4%、72.4%;其它血清型菌的耐藥率分彆是:98.2%、92.9%、5.4%、0、35.7%.;僅青黴素耐藥率有統計學意義差彆.結論 重慶地區臨床分離的肺炎鏈毬菌的常見血清型與其它地區報道有一定差彆.對左氧氟沙星、頭孢唑林耐藥率低,對青黴素的耐藥率與國內報道接近,但對于阿奇黴素及剋林黴素的耐藥率高.常見血清型肺炎鏈毬菌對青黴素的耐藥率明顯高于其它血清型.
목적 료해중경지구적림상분리폐염련구균적상견혈청형분포급기내약정황,병대상견혈청형균주화기타혈청형균주적내약정황진행비교.방법 응용협막종창실험검측2006년1월～2008년8월림상분리적143주폐염련구균적혈청형,병채용경지희석법검측상용항균약물적최저억균농도(MIC).결과 총적상견혈청형위형/군위19군、6군、5형、10군、15군,단종성인분리적균주상견혈청형위19군、10군、5형、33군,인동칙이19군、6군、15군화23군혈청형위주.143주균대아기매소、극림매소、좌양불사성、두포서림、청매소적내약솔(내약+중개)분별시97.9%、95.8%、4.2%、0.7%、58.1%,대우청매소적민감솔시42%.상견혈청형폐염련구균대5충항균소적내약솔(내약+중개)분별시:97.7%、97.7%、1.1%、3.4%、72.4%;기타혈청형균적내약솔분별시:98.2%、92.9%、5.4%、0、35.7%.;부청매소내약솔유통계학의의차별.결론 중경지구림상분리적폐염련구균적상견혈청형여기타지구보도유일정차별.대좌양불사성、두포서림내약솔저,대청매소적내약솔여국내보도접근,단대우아기매소급극림매소적내약솔고.상견혈청형폐염련구균대청매소적내약솔명현고우기타혈청형.
Objective To investigate antibiotic resistance and the prevalence of serotype of clinical Streptococcus pneumoniae in Chongqing. Methods One hundred and forty-three strains were isolated from in-paterns in four teaching hospitals in chongqing during 2006～2008. Minimal inhibition concentrations (MlC) of 5 kinds of antibiotics were determined by agar dilution method. The 143 strains were typed by the pneumotest-kit. Results Among 143 strains of Streptococcus pneumonia, the most prevalent serogroups/ serotypes are type 19,6 4,15,10 and 33. The rest 15 strains were unable to classify their serotypes. The common serogroup/serotypes of 63 clinical isolates from children are type 19, 6,15,14 and 23, while those from adults (80 strains) are type 19,5,10 and 33. Of all isolates, penicillin susceptible rate is 42%; clindamycin and azthromycin resistance were 94.4% and 97.9% respectively, worthy to calling for clinical attention. The Strains resistant to levofloxacin and cefazolin were found for 4.2%, and 0.7%. Penicillin susceptible rate of the most common serogroup/serotypes was 27.6%, while those of uncommon serogroup/serotypes were 64.3%. The azthromycin, clindamycin, levofloxacin, cefazolin and penicillin resistance rates for the common serogroup/serotypes strains were 97.7%, 97.7%, 1.1%, 3.4% and 72.4% .respectively; while those of the uncommon serogroup/serotypes were 98.2%, 92.9%, 5.4%, 0 and 35.7% respectively.Conclusions Among 143 strains of S. pneumoniae, The most prevalent serogroups/ serotypes are 19 ,6 ,5,15,10 and 33, the most common serotypes of the clinical isolates from children were different from adults. The isolates in Chongqing had higher penicillin susceptibility than those in other area. The isolates had a significantly higher susceptible rate of levofloxacin and cefazolin, but the isolates had a higher clindamycin and azthromycin resistance. The most prevalent serogroups/ serotypes had a different resistance rate to penicillin compared with the uncommon serogroup/serotypes isolates.
