CAJ | 학술논문

目的了解基因重组生长激素(r-hGH)是否可以改善特发性身材矮小(ISS)男童的最终成人身高(FAH).方法测量了16例当年诊断为ISS男童FAH,共分两组,其中观察组9例未予r-hGH治疗,治疗组7例接受了r-hGH治疗,剂量为0.1～0.13 U·kg-1·d-1,临睡前皮下注射,疗程为6～20(11.9±5.2)个月.结果治疗组平均FAH较观察组的平均FAH有明显提高(t=2.219,P<0.05).结论 r-hGH可改善ISS男童的FAH,但要早期治疗,疗程越长效果越明显.
목적 료해기인중조생장격소(r-hGH)시부가이개선특발성신재왜소(ISS)남동적최종성인신고(FAH).방법 측량료16례당년진단위ISS남동FAH,공분량조,기중관찰조9례미여r-hGH치료,치료조7례접수료r-hGH치료,제량위0.1～0.13 U·kg-1·d-1,림수전피하주사,료정위6～20(11.9±5.2)개월.결과 치료조평균FAH교관찰조적평균FAH유명현제고(t=2.219,P<0.05).결론 r-hGH가개선ISS남동적FAH,단요조기치료,료정월장효과월명현.
Objective In order to understand whether recombinant human growth hormone(r-hGH) can improve the idiopathic short stature(ISS) boys' final adult height(FAH).Methods We measured 16 cases diagnosed as ISS boys FAH, divided into 2 groups, of which 9 cases were not given r-hGH treatment, treatment group ,7 patients received r-hGH treatment, a dose of 0.1 ～ 0.13 U· kg-1·d-1, before going to sleep subcutaneous injection, duration of treatment was 6 ～ 20 months ( 11.9 ± 5.2 months).Results The treatment group compared with the average FAH FAH observation group had significantly improved the average(t =2.219,P<0.05).Conclusion r-hGH can improve the ISS boys FAH, but early treatment, the longer the course the more obvious effects.