中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2012年
4期
266-269
,共4页
先天性胆总管囊肿%胆管癌%凋亡抑制蛋白
先天性膽總管囊腫%膽管癌%凋亡抑製蛋白
선천성담총관낭종%담관암%조망억제단백
Congenital choledochal cyst%Cholangiocarcinoma%Survivin
目的 探讨凋亡抑制蛋白基因(survivin)在先天性胆总管囊肿和胆管癌组织中的表达及意义.为进一步研究胆总管囊肿癌变的机制奠定理论基础.方法 采用免疫组化SP法检测Survivin在37例先天性胆总管囊肿组织(其中儿童20例,成人17例)和10例胆管癌组织中的表达,10例正常胆管作为对照.运用SPSS14.0统计学软件处理数据.结果 Survivin在37例先天性胆总管囊肿组织中,11例为阴性,15例弱阳性表达,9例阳性表达,2例强阳性表达.而在10例胆管癌组织中,Survivin有5例阳性和5例强阳性表达,未见阴性表达.正常胆管组织中仅有1例弱阳性表达,两两相比差异有统计学意义(P＜0.01).Survivin在成人胆总管囊肿中的表达强于儿童组,两者间差异有统计学意义(P＜0.01).结论 Survivin参与了胆总管囊肿癌变过程,可能与癌变的发生发展有关,在先天性胆总管囊肿癌变过程中可能起到促进作用.
目的 探討凋亡抑製蛋白基因(survivin)在先天性膽總管囊腫和膽管癌組織中的錶達及意義.為進一步研究膽總管囊腫癌變的機製奠定理論基礎.方法 採用免疫組化SP法檢測Survivin在37例先天性膽總管囊腫組織(其中兒童20例,成人17例)和10例膽管癌組織中的錶達,10例正常膽管作為對照.運用SPSS14.0統計學軟件處理數據.結果 Survivin在37例先天性膽總管囊腫組織中,11例為陰性,15例弱暘性錶達,9例暘性錶達,2例彊暘性錶達.而在10例膽管癌組織中,Survivin有5例暘性和5例彊暘性錶達,未見陰性錶達.正常膽管組織中僅有1例弱暘性錶達,兩兩相比差異有統計學意義(P＜0.01).Survivin在成人膽總管囊腫中的錶達彊于兒童組,兩者間差異有統計學意義(P＜0.01).結論 Survivin參與瞭膽總管囊腫癌變過程,可能與癌變的髮生髮展有關,在先天性膽總管囊腫癌變過程中可能起到促進作用.
목적 탐토조망억제단백기인(survivin)재선천성담총관낭종화담관암조직중적표체급의의.위진일보연구담총관낭종암변적궤제전정이론기출.방법 채용면역조화SP법검측Survivin재37례선천성담총관낭종조직(기중인동20례,성인17례)화10례담관암조직중적표체,10례정상담관작위대조.운용SPSS14.0통계학연건처리수거.결과 Survivin재37례선천성담총관낭종조직중,11례위음성,15례약양성표체,9례양성표체,2례강양성표체.이재10례담관암조직중,Survivin유5례양성화5례강양성표체,미견음성표체.정상담관조직중부유1례약양성표체,량량상비차이유통계학의의(P＜0.01).Survivin재성인담총관낭종중적표체강우인동조,량자간차이유통계학의의(P＜0.01).결론 Survivin삼여료담총관낭종암변과정,가능여암변적발생발전유관,재선천성담총관낭종암변과정중가능기도촉진작용.
Objective To investigate the expression of survivin and its significance in congenital choledochal cyst and cholangiocarcinoma.Methods Immunohistochemical (S-P) techique was used to detect survivin in 37 patients with congenital choledochal cyst (children,n=20,adult,n=7),and 10 patients with cholangiocarcinoma.Ten patients with normal or benign bile duct lesions were used as control.Results In congenital choledochal cyst,the tissue was strongly positive for 2 patients,positive for 9 patients,weakly positive for 15 patients,and negative for 11 patients.In cholangiocarcinoma,the tissue was strongly positive in 5 patients and positive in 5 patients.In normal bile duct the tissue was weakly positive in 1 patient.The difference among the groups was significant (P＜0.01).The difference in expression of survivin between adults and children with congenital choledochal cyst was significant.Conclusions Survivin may play a pivotal role in malignant change,tumorigenesis,and tumor progression in congenital choledochal cyst.
