CAJ | 학술논문

目的观察北京市奥运会期间大气污染物浓度变化情况,及其与人群心率变异性(HRV)之间的相关关系.方法采用定组研究设计,筛选26例患有冠心病、心绞痛或具有至少1年以上心肌缺血症状的患者作为研究对象,在2008年6-9月进行5个周期的随访,测量其HRV指标及其他相关指标;收集同时期北京市环保局和气象局公布的每日大气污染物资料和气象资料,利用混合效应模型分析大气污染物浓度与人群HRV之间的相关关系.结果通过单污染物线性混合效应发现HRV中总功率和高频功率与污染物大气颗粒物(PM10)、二氧化硫(SO2)和二氧化氮(SO2)浓度均呈负相关关系,PM10、SO2和NO2的浓度每下降10μg/m3总功率分别上升2.51%(95%CI值:-3.80%～-1.22%,t=-1.99,P=0.0497)、31.39%(95%CI值:-52.24%～-10.53%,t=-1.99,P=0.0497)和42.72%(95%CI值:-75.06%～-10.38%,t=-1.99,P=0.0497);高频功率分别上升3.46%(95%CI值:-5.14%～-1.77%,t=-2.11,P=0.0378)、40.63%(95%CI值:-68.70%～-12.56%,t=-2.11,P=0.0378)和53.76%(95%CI值:-97.97%～-9.56%,t=-2.11,P=0.0378).结论大气污染物浓度的降低可改善易感人群的心血管功能.
목적 관찰북경시오운회기간대기오염물농도변화정황,급기여인군심솔변이성(HRV)지간적상관관계.방법 채용정조연구설계,사선26례환유관심병、심교통혹구유지소1년이상심기결혈증상적환자작위연구대상,재2008년6-9월진행5개주기적수방,측량기HRV지표급기타상관지표;수집동시기북경시배보국화기상국공포적매일대기오염물자료화기상자료,이용혼합효응모형분석대기오염물농도여인군HRV지간적상관관계.결과 통과단오염물선성혼합효응발현HRV중총공솔화고빈공솔여오염물대기과립물(PM10)、이양화류(SO2)화이양화담(SO2)농도균정부상관관계,PM10、SO2화NO2적농도매하강10μg/m3총공솔분별상승2.51%(95%CI치:-3.80%～-1.22%,t=-1.99,P=0.0497)、31.39%(95%CI치:-52.24%～-10.53%,t=-1.99,P=0.0497)화42.72%(95%CI치:-75.06%～-10.38%,t=-1.99,P=0.0497);고빈공솔분별상승3.46%(95%CI치:-5.14%～-1.77%,t=-2.11,P=0.0378)、40.63%(95%CI치:-68.70%～-12.56%,t=-2.11,P=0.0378)화53.76%(95%CI치:-97.97%～-9.56%,t=-2.11,P=0.0378).결론 대기오염물농도적강저가개선역감인군적심혈관공능.
Objective To observe the variations of the concentrations of air pollutants and explore the correlation between the heart rate variability (HRV) of the aged people and the air quality during Beijing Olympic Games 2008. Methods A panel study design was adopted. A total of twenty-six over 55-year-old patients with coronary heart disease or anginapectoris or a symptom of myocardial ischemia at least for one year were enrolled as a panel and followed up five times by measuring HRV index and other related indexes from June to September in 2008. The correlations between the HRV of the aged people and the air quality was analyzed with the linear mixed-effect models according to the data of air pollutants and meteorological conditions collected simultaneously from Beijing Environmental Protection Bureau and Beijing Meteorological Bureau. Results In single-pollutant mixed-effect models, the significant correlation was observed in the reduction of ambient PM10 ,SO2 and NO2 with the improvement of the total power and high-frequency power (HF) of HRV in the panel subjects,and a 10 μg/m3 decrease in PM10 ,SO2 and NO2 level was correlated with 2.51%(95%CI: -3.80% - -1.22% ,t= - 1.99,P=0.0497),31.39% (95% CI: -52.24% --10.53%,t= -1.99,P=0.0497) and 42.72% (95%CI: -75.06% - -10.38%,t= -1.99,P=0.0497) rises in total power of HRV respectively. A 10 μg/m3 decrease in PM10,SO2 and NO2 level was correlated with 3.46% (95% CI: -5.14% - - 1.77% ,t= -2.11 ,P=0.0378),40. 63% (95% CI: -68.70%--12.56%,t= -2.11,P=0.0378) and 53.76% (95%CI: -97.97% - -9.56%,t= -2. 11,P = 0. 0378) rises in high-frequency power (HF) of HRV respectively. Conclusion It suggests that the air pollution reduction could improve the cardiovascular functions of the susceptible population.