CAJ | 학술논문

抗菌蛋白是机体先天性防御系统的构成成分,在防御病原入侵方面起十分重要作用.虽然一些抗菌蛋白成分的表达是组成性的,但最新研究表明,许多抗菌蛋白的表达受到相关细胞因子的调控,尤其是T细胞系来源的细胞因子所发挥的作用最为显著.了解细胞因子介导的抗菌蛋白表达调控机制及IL-17和IL-22如何通过调节局部的相关抗菌蛋白表达来保持皮肤和粘膜免疫稳态性的很重要.
항균단백시궤체선천성방어계통적구성성분,재방어병원입침방면기십분중요작용.수연일사항균단백성분적표체시조성성적,단최신연구표명,허다항균단백적표체수도상관세포인자적조공,우기시T세포계래원적세포인자소발휘적작용최위현저.료해세포인자개도적항균단백표체조공궤제급IL-17화IL-22여하통과조절국부적상관항균단백표체래보지피부화점막면역은태성적흔중요.
Antimicrebial proteins (AMP) are components of innate immune system of the body, which are cru-cial in defense against pathogenic invasion. Although it was believed that they are constitutionally expressed, recent studies demonstrated that expressions of many AMPs are inducible and mostly regulated by T cell line-de-rived cytokines. This article aimed mainly to introduce the mechanisms underlying regulation of antimicrobial protein expression by cytokines, with stressing on relating novel understanding of contribution made by IL-17, IL-22 to immune homeostasis in the skin and mucosa through regulating local AMP expression.