CAJ | 학술논문

从细胞培养、啮齿类动物和非人类灵长类动物的实验研究中得到越来越多的证据:临床常用全麻药物对各期脑神经细胞产生毒性作用,损伤中枢神经系统,特别对处于发育高峰期的大脑影响更大,并影响以后的学习记忆功能.现综述这些事实及目前全麻药物神经毒性作用的机制假设,目的是让人们对全麻药物毒性作用的最新研究进展有一了解,转变临床麻醉的一些观念.
종세포배양、교치류동물화비인류령장류동물적실험연구중득도월래월다적증거:림상상용전마약물대각기뇌신경세포산생독성작용,손상중추신경계통,특별대처우발육고봉기적대뇌영향경대,병영향이후적학습기억공능.현종술저사사실급목전전마약물신경독성작용적궤제가설,목적 시양인문대전마약물독성작용적최신연구진전유일료해,전변림상마취적일사관념.
A growing body of evidence from cells culture, rodents and sub-human primates's experimental study suggest that clinical commonly used general anesthetics not only can cause neurotoxicity to neuronal cells of different periods with subsequent central nervous system injury, especially during the brain growth spurt period, but also affect learning and memory function. We review the evidence of neurotoxic effects of anesthetic agents and hypothesis of mechanism, in order to allow people to understand the latest research progress of general anesthetics on toxic effects and change some concept of clinical anesthesia.