国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2011年
5期
285-288
,共4页
脊柱炎,强直性%骨关节炎,髋%滑膜切除术%磷放射性同位素%药物疗法%磷酸铬胶体
脊柱炎,彊直性%骨關節炎,髖%滑膜切除術%燐放射性同位素%藥物療法%燐痠鉻膠體
척주염,강직성%골관절염,관%활막절제술%린방사성동위소%약물요법%린산락효체
Spondylitis,ankylosing%Osteoarthritis,hip%Phosphorus radioisotopes%Synovectomy%Drug therapy%Chromic phosphate colloid
目的 观察32P-磷酸铬胶体滑膜切除术联合常规药物治疗强直性脊柱炎髋关节病变的疗效.方法 强直性脊柱炎单侧髋关节病变住院患者84例,分别人组常规药物联合32P-磷酸铬胶体滑膜切除术组(联合治疗组)和单用常规药物组(对照组)各42例,观察其疗效和安全性.结果 随访6个月,联合治疗组和对照组有效率分别为73.8％和52.4％,联合治疗组显著优于对照组(x2=4.840,P＜0.05)；随访3年,有效率分别为53.8％和47.6％,两组比较无统计学意义(x2=0.047,P＞0.05).随访3年髋关节X线分期出现进展,联合治疗组与对照组比较差异显著(x2=5.516,P＜0.05).随访6个月及随访3年,联合治疗组和对照组分别与治疗前Bath强直性脊柱炎病情活动指数(BAS-DAI)评分的差值比较,差异均无统计学意义(t=1.303,P＞0.05及t=1.759,P＞0.05).随访6个月,联合治疗组和对照组的髋关节视觉模拟评分(VAS)与治疗前的差值比较差异显著(t=2.389,P＜0.05),而随访3年,联合治疗组和对照组的髋关节VAS评分与治疗前的差值比较,其差异无统计学意义(t=1.632,P＞0.05).不良反应仅见5例出现一过性关节疼痛加重.结论 32P-磷酸铬胶体滑膜切除术联合常规药物治疗强直性脊柱炎髋关节病变有一定近期疗效.
目的 觀察32P-燐痠鉻膠體滑膜切除術聯閤常規藥物治療彊直性脊柱炎髖關節病變的療效.方法 彊直性脊柱炎單側髖關節病變住院患者84例,分彆人組常規藥物聯閤32P-燐痠鉻膠體滑膜切除術組(聯閤治療組)和單用常規藥物組(對照組)各42例,觀察其療效和安全性.結果 隨訪6箇月,聯閤治療組和對照組有效率分彆為73.8％和52.4％,聯閤治療組顯著優于對照組(x2=4.840,P＜0.05)；隨訪3年,有效率分彆為53.8％和47.6％,兩組比較無統計學意義(x2=0.047,P＞0.05).隨訪3年髖關節X線分期齣現進展,聯閤治療組與對照組比較差異顯著(x2=5.516,P＜0.05).隨訪6箇月及隨訪3年,聯閤治療組和對照組分彆與治療前Bath彊直性脊柱炎病情活動指數(BAS-DAI)評分的差值比較,差異均無統計學意義(t=1.303,P＞0.05及t=1.759,P＞0.05).隨訪6箇月,聯閤治療組和對照組的髖關節視覺模擬評分(VAS)與治療前的差值比較差異顯著(t=2.389,P＜0.05),而隨訪3年,聯閤治療組和對照組的髖關節VAS評分與治療前的差值比較,其差異無統計學意義(t=1.632,P＞0.05).不良反應僅見5例齣現一過性關節疼痛加重.結論 32P-燐痠鉻膠體滑膜切除術聯閤常規藥物治療彊直性脊柱炎髖關節病變有一定近期療效.
목적 관찰32P-린산락효체활막절제술연합상규약물치료강직성척주염관관절병변적료효.방법 강직성척주염단측관관절병변주원환자84례,분별인조상규약물연합32P-린산락효체활막절제술조(연합치료조)화단용상규약물조(대조조)각42례,관찰기료효화안전성.결과 수방6개월,연합치료조화대조조유효솔분별위73.8％화52.4％,연합치료조현저우우대조조(x2=4.840,P＜0.05)；수방3년,유효솔분별위53.8％화47.6％,량조비교무통계학의의(x2=0.047,P＞0.05).수방3년관관절X선분기출현진전,연합치료조여대조조비교차이현저(x2=5.516,P＜0.05).수방6개월급수방3년,연합치료조화대조조분별여치료전Bath강직성척주염병정활동지수(BAS-DAI)평분적차치비교,차이균무통계학의의(t=1.303,P＞0.05급t=1.759,P＞0.05).수방6개월,연합치료조화대조조적관관절시각모의평분(VAS)여치료전적차치비교차이현저(t=2.389,P＜0.05),이수방3년,연합치료조화대조조적관관절VAS평분여치료전적차치비교,기차이무통계학의의(t=1.632,P＞0.05).불량반응부견5례출현일과성관절동통가중.결론 32P-린산락효체활막절제술연합상규약물치료강직성척주염관관절병변유일정근기료효.
Objective To observe the therapeutic effect of 32P-chromic phosphate colloidal synovectomy combined with routine medication in the treatment of the hip disease of ankylosing spondylitis.Method Eight-two ankylosing spondylitis unilateral hip patients were divided into two groups.Forty-two were enrolled in the routine medication combined with 32P-chromic phosphate colloidal synovectomy group (treatment group) and 42 in conventional medicine group(control group).The efficacy and safety were observed.Resuts The effective rate of treatment group and control group were 73.8％ and 52.4％ respectively in the following six months.The difference was significant (x2=4.840,P＜0.05).The effective rate were respectively 53.8％ and 47.6％ in three-year follow-up,with no significant difference between the two groups (x2=0.047,P＞0.05 ).There was progress on the X-ray phases of hip joint in three-year follow-up,for the difference between the treatment group and the control group was significant (x2=5.516,P ＜0.05).During the different follow-up time,six months and three years,there were differences in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) before and after treatment between the treatment group and the control group,but the differences were not statistically significant ( t =1.303,t=1.759,P all＞0.05 ).When followed up for 6 months,the differences in the visual analogue scale(VAS) for hip of the treatment group and the control group were statistically different between before and after treatment(t=2.389,P＜0.05 ).But when followed up for three years,the differences were not statistically different (t=1.632,P＞0.05).The side effects was ob served only in five cases which was transient pain increase in joints.Conclusion 32P-chromic phosphate colloid synovectomy combined with routine medication had a short-term effect in treating the hip joint disease of ankylosing spondylitis.
