国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2012年
2期
120-123
,共4页
斑秃%T淋巴细胞,调节性%自身免疫
斑禿%T淋巴細胞,調節性%自身免疫
반독%T림파세포,조절성%자신면역
Alopecia areata%T-lymphocytes,regulatory%Autoimmunity
CD4+CD25调节性T细胞是T细胞中具有免疫调节功能的主要细胞群,在调节免疫应答和维持外周免疫耐受中起重要作用.CD4+CD25调节性T细胞的数量减少或功能缺失可能导致自身免疫病的发生.斑秃是一种T细胞介导的累及毛囊的器官特异性自身免疫性疾病.斑秃的动物实验和临床研究均发现,斑秃时存在CD4+CD25+调节性T细胞异常,提示CD4+CD25+调节性T细胞可能参与了斑秃的自身免疫发病机制.
CD4+CD25調節性T細胞是T細胞中具有免疫調節功能的主要細胞群,在調節免疫應答和維持外週免疫耐受中起重要作用.CD4+CD25調節性T細胞的數量減少或功能缺失可能導緻自身免疫病的髮生.斑禿是一種T細胞介導的纍及毛囊的器官特異性自身免疫性疾病.斑禿的動物實驗和臨床研究均髮現,斑禿時存在CD4+CD25+調節性T細胞異常,提示CD4+CD25+調節性T細胞可能參與瞭斑禿的自身免疫髮病機製.
CD4+CD25조절성T세포시T세포중구유면역조절공능적주요세포군,재조절면역응답화유지외주면역내수중기중요작용.CD4+CD25조절성T세포적수량감소혹공능결실가능도치자신면역병적발생.반독시일충T세포개도적루급모낭적기관특이성자신면역성질병.반독적동물실험화림상연구균발현,반독시존재CD4+CD25+조절성T세포이상,제시CD4+CD25+조절성T세포가능삼여료반독적자신면역발병궤제.
CD4+CD25+ regulatory T cells (Tregs),a predominant cell subset with immunomodulatory properties,play an important role in the modulation of immune response and maintenance of peripheral immune tolerance.The dysfunction or deficiency of Tregs may induce the development of various autoimmune diseases.Alopecia areata (AA) is an organ-specific,T-cell mediated autoimmune disease of hair follicles.Studies have revealed abnormal changes of Tregs in animal models of and patients with AA,indicating that Tregs may be involved in the pathogenesis of AA.
