CAJ | 학술논문

目的探讨缺血修饰白蛋白(IMA)对急性心肌梗死(AMI)的早期诊断价值.方法 103例胸痛发作患者分别于入院即刻及4、6、12、24h连续监测IMA、肌钙蛋白I(cTnI)、肌酸激酶同工酶MB(CK-MB)三项指标,观察其变化规律,同时选择30例健康对照进行检测.结果 23例患者最终诊断为AMI；入院即刻IMA、CK-MB、cTnI检测的敏感性、特异性分别为IMA 89.3％、91.3％,CK-MB 48.4％、92.3％,cTnI 30.6％、93.7％；入院6h内,IMA、CK-MB、cTnI的敏感性分别为91.3％、34.8％、52.2％,联合检测敏感性为100.0％,三者比较差异有统计学意义(x2=15.99,P＜0.01).结论 IMA对AMI的早期诊断有较高的价值,IMA联合cTnI、CK-MB检测诊断AMI,其敏感性明显优于单项检测,具有重要的临床应用价值.
목적 탐토결혈수식백단백(IMA)대급성심기경사(AMI)적조기진단개치.방법 103례흉통발작환자분별우입원즉각급4、6、12、24h련속감측IMA、기개단백I(cTnI)、기산격매동공매MB(CK-MB)삼항지표,관찰기변화규률,동시선택30례건강대조진행검측.결과 23례환자최종진단위AMI；입원즉각IMA、CK-MB、cTnI검측적민감성、특이성분별위IMA 89.3％、91.3％,CK-MB 48.4％、92.3％,cTnI 30.6％、93.7％；입원6h내,IMA、CK-MB、cTnI적민감성분별위91.3％、34.8％、52.2％,연합검측민감성위100.0％,삼자비교차이유통계학의의(x2=15.99,P＜0.01).결론 IMA대AMI적조기진단유교고적개치,IMA연합cTnI、CK-MB검측진단AMI,기민감성명현우우단항검측,구유중요적림상응용개치.
Objective To investigate the value of ischemia modified albumin (IMA) detection in preliminary diagnosis of acute myocardial infarction (AMI).Methods The levels and variations of IMA,cTnI and CK-MB in 103 patients with acute chest pain were measured continuously at 0,4,6,12,24 hours after admission respectively.Thirty healthy subjects were observed as normal controls.Results Twenty three patients were diagnosed as AMI in the end,the sensitivity and specificity rates right after admission were 89.3％ and91.3％ for IMA,48.4％ and 92.3％ for CK-MB,30.6％ and 93.7％ for cTnI respectively.The sensitivity values at the 6th hours after admission were 91.3％ for IMA,52.2％ for CTnI and 34.8％ for CK-MB respectively.The specificity was 100.0％ when the IMA was detected in combination with CK-MB or cTnI.The sensitivity of co-detection was significantly higher than that any single detection at sixth hours after admission (x2 =15.99,P ＜ 0.01 ).Conclusion Plasma IMA assessment is helpful for early diagnosis of AMI,and will significantly improve the sensitivity early diagnosis of AMI.The co-detection of IMA and CK-MB or cTnI obviously surpasses any single detection,and has extremely vital clinical significance.