CAJ | 학술논문

青光眼是重要的不可逆转的致盲性眼病，药物治疗是其主要干预手段，尤其是原发性开角型青光眼。对于基线眼压较高的青光眼患者，单一用药往往不能有效控制眼压至安全水平，因此需选择联合用药方式。传统非固定配方的青光眼联合用药法存在用药次数多、频率高，影响患者正常工作和生活，影响用药依从性，增加药物防腐剂在眼局部浓度等问题。因此，研究新型的青光眼固定配方复合制剂成为青光眼药物治疗的新方向，有必要对目前青光眼新型固定配方复合制剂的优缺点、临床疗效评价等方面的研究进展作一综述。
청광안시중요적불가역전적치맹성안병，약물치료시기주요간예수단，우기시원발성개각형청광안。대우기선안압교고적청광안환자，단일용약왕왕불능유효공제안압지안전수평，인차수선택연합용약방식。전통비고정배방적청광안연합용약법존재용약차수다、빈솔고，영향환자정상공작화생활，영향용약의종성，증가약물방부제재안국부농도등문제。인차，연구신형적청광안고정배방복합제제성위청광안약물치료적신방향，유필요대목전청광안신형고정배방복합제제적우결점、림상료효평개등방면적연구진전작일종술。
Glaucoma is a common cause of visual impairment and irreversible blindness. Medication is important in the management of glaucoma, especially in primary open-angle glaucoma. Combination drug therapy is needed because single drug therapy can not always control the intraocular pressure effectively to a safe level in glaucoma patients with higher baseline intraocular pressure. Traditional unfixed combination therapy of glaucoma may disturb daily life because the frequency of admitting eye-drops is increased, it is less persistence or compliance, and results in the increase of local concentration of preservatives in the eye.The new fixed combination formulations for glaucoma have been developed to be safer, more effect and more compliable. This article reviews the comparative studies of therapeutic effects of anti-glaucoma fixed combination formulation and summarizes features of each formulation, and then prospects the new developing tendency of anti-glaucoma medication.