CAJ | 학술논문

　　研究截短侧耳素的萃取和结晶。截短侧耳素闪蒸粉分别用甲醇、乙醇和K酮在20℃、40℃和60℃条件下萃取，萃取时间60 min，比较萃取率；60℃的K酮饱和溶液，分别降温至50℃、45℃和40℃，加入晶种保温3h，然后以5~8℃/h的速度降温至0℃，然后保温2h，离心获得晶体，50℃干燥1h，获得截短侧耳素粉，分析干燥失重、含量、杂质和收率。K酮在60℃时的萃取率最高，均值为92%；40℃加入晶种保温3h获得产品收率最高95.01%。K酮为更加理想的截短侧耳素萃取剂，萃取温度60℃，晶体成长的第一过程选择40℃。
　　연구절단측이소적췌취화결정。절단측이소섬증분분별용갑순、을순화K동재20℃、40℃화60℃조건하췌취，췌취시간60 min，비교췌취솔；60℃적K동포화용액，분별강온지50℃、45℃화40℃，가입정충보온3h，연후이5~8℃/h적속도강온지0℃，연후보온2h，리심획득정체，50℃간조1h，획득절단측이소분，분석간조실중、함량、잡질화수솔。K동재60℃시적췌취솔최고，균치위92%；40℃가입정충보온3h획득산품수솔최고95.01%。K동위경가이상적절단측이소췌취제，췌취온도60℃，정체성장적제일과정선택40℃。
Research extraction and crystallization of pleuromutilin. Pleuromutilin flash powder with methanol, ethanol and K ketone was extracted at 20℃, 40℃and 60℃, extraction time 60 min, compared extraction rate. K ketone saturated solution at 60 ℃ was cooled to 50 ℃, 45℃ and 40 ℃, respectively, with addition of crystal warmed for 3h, and then cooled to 0℃at the speed of 5-8℃per 1 hour, then warmed for 2h, centrifugated for crystal, dryed for 1h at 50℃, obtained pleuromutilin powder, loss on drying, content analysis, impurity and yield. K ketone extraction rate is the highest at 60℃, average is 92%. At 40℃by adding crystal seeds obtained the highest yield products 95.01%for 3h. K ketone as truncated ear is more ideal element extractant, extraction tem-perature 60℃, crystal growth process at 40℃first choice.