CAJ | 학술논문

背景:糖尿病发病率可预测其发展趋势,目前国内糖尿病发病率较以前有所升高.目的:对糖耐量低减和正常人群的糖尿病发病率进行比较,分析相关影响因素的危险性.设计:以广西柳州市2个社区的成年人为研究对象的整群抽样调查.单位:一所大学医院的内分泌科.对象:1994-07/08对柳州市4个较大单位社区的人群进行糖尿病患病率调查,常住人口11886名,均为20～75岁的成年人,且在柳州市城乡居住5年以上.1999-10对其中2个单位社区的糖耐量低减和正常者进行随访,应查9 230例,实查6 020例,反映率65.22%(因下岗、退休等原因失访人数较多).纳入标准:最终两次资料均完整者5 539例进入统计.正常者5 273例,糖耐量低减者266例;男3 177例,含糖耐量低减110例,平均年龄(40±12)岁;女2 362例,含糖耐量低减156例,平均年龄(41±10)岁.排除标准:继发性糖尿病.方法:1994年广西柳州市2个单位社区糖尿病患病率调查中确定为非糖尿病(包括糖耐量低减和正常人)的5 539例,于1999年复查血糖、体质量指数、血压及血脂,分析各因素对糖尿病发病率的影响.主要观察指标:①终点结局指标:各年龄组糖尿病发病率.②危险性指标:糖尿病发病率相关危险因素比较.结果:纳入统计5 539例.5 273例正常者中,46例转变为糖尿病,年转化率为0.19%;而266例糖耐量低减者中,50例转化为糖尿病,年转化率为3.84%,相对危险性是正常人的20.9倍,差异有显著性意义(x2=1 063.1,P<0.000 1).结论:糖耐量低减者转化为糖尿病的危险性远高于正常人.年龄、体质量指数、高血压、空腹血糖、血糖、葡萄糖耐量试验1 h血糖、葡萄糖耐量试验2 h血糖是糖尿病发病的危险因素.
배경:당뇨병발병솔가예측기발전추세,목전국내당뇨병발병솔교이전유소승고.목적:대당내량저감화정상인군적당뇨병발병솔진행비교,분석상관영향인소적위험성.설계:이엄서류주시2개사구적성년인위연구대상적정군추양조사.단위:일소대학의원적내분비과.대상:1994-07/08대류주시4개교대단위사구적인군진행당뇨병환병솔조사,상주인구11886명,균위20～75세적성년인,차재류주시성향거주5년이상.1999-10대기중2개단위사구적당내량저감화정상자진행수방,응사9 230례,실사6 020례,반영솔65.22%(인하강、퇴휴등원인실방인수교다).납입표준:최종량차자료균완정자5 539례진입통계.정상자5 273례,당내량저감자266례;남3 177례,함당내량저감110례,평균년령(40±12)세;녀2 362례,함당내량저감156례,평균년령(41±10)세.배제표준:계발성당뇨병.방법:1994년엄서류주시2개단위사구당뇨병환병솔조사중학정위비당뇨병(포괄당내량저감화정상인)적5 539례,우1999년복사혈당、체질량지수、혈압급혈지,분석각인소대당뇨병발병솔적영향.주요관찰지표:①종점결국지표:각년령조당뇨병발병솔.②위험성지표:당뇨병발병솔상관위험인소비교.결과:납입통계5 539례.5 273례정상자중,46례전변위당뇨병,년전화솔위0.19%;이266례당내량저감자중,50례전화위당뇨병,년전화솔위3.84%,상대위험성시정상인적20.9배,차이유현저성의의(x2=1 063.1,P<0.000 1).결론:당내량저감자전화위당뇨병적위험성원고우정상인.년령、체질량지수、고혈압、공복혈당、혈당、포도당내량시험1 h혈당、포도당내량시험2 h혈당시당뇨병발병적위험인소.
BACKGROUND: Diabetic morbidity can predict its progress tendency. National diabetic morbidity has been increased compared with previous level at present.OBJECTIVE: To compare the diabetic morbidity between populations with impaired glucose tolerance or normal blood glucose tolerance to analyze its correlative influencing factors.DESIGN: A cluster sampling survey in two communities of Liuzhou City Guangxi Zhuang Autonomous Region based on adults.SETTING: Department of endocrinology in a university hospital.PARTICIPANTS: Diabetic morbidity was investigated in 4 relative big unit communities of Liuzhou City between July and August 1994. The resident population of the communities was 11 886, which were all adults between 20 and 75 years old and lived in Liuzhou City for more than 5 years. Populations with either impaired glucose tolerance or normal blood glucose tolerance in 2 of the 4 unit communities were followed up in October 1999. Totally 9 230 individuals should be checked and 6 020 subjects were actually checked with the response rate of 65.22% (quite a few cases lost followed up due to unemployment and retirement, etc. ) . Inclusion criteria: Finally 5 539 subjects with complete data of two surveys entered into statistics. There were 5 237 normal individuals and 266 individuals with impaired glucose tolerance. And there were 3 177 males including 110 individuals with impaired glucose tolerance with an average age of(40 ± 12) years old, and 2 362 females including 156 individuals with impaired glucose tolerance with an average age of(41 ± 10) years old. Exclusion criterion: secondary diabetes.METHODS: Totally 5 539 subjects(including individuals with normal blood glucose or impaired glucose tolerance) who confirmed without diabetes in 1994 survey for diabetic morbidity in 2 unit communities of Liuzhou City Gugangxi Zhuang Autonomous Region received recheck in 1999 including blood glucose, body mass index(BMI), blood pressure and blood fat to analyze the impacts of each factor on diabetic morbidity.bidity among correlative risk factors.RESULTS: Totally 5 539 individuals were included into statistics. A totally of 46 of 5 237 normal individuals developed diabetes with the annual percent of conversion of 0.19%, while 50 of 226 individuals with impaired glucose tolerance developed diabetes with the annual percent of conversion of 3.84%, which had 20.9 times of correlative risk significantly higher than normal individuals(x2 = 1 063.1, P < 0. 000 1).CONCLUSION: The risk of diabetes is higher in individuals with impaired glucose tolerance than normal individuals. Age, BMI, hypertension, fasting blood glucose, blood glucose, and 1 hour blood glucose in Glucose tolerance test are risk factors of diabetic morbidity.