CAJ | 학술논문

缺氧诱导因子-1(hy poxia-inducible factor-1,HIF-1)是一种重要的转录调节因子,主要通过其活性亚基HIF-1α参与机体对缺氧环境的应答.脑缺血缺氧时,HIF-1α表达上调,可激活涉及糖酵解、血管生长、细胞生存和细胞凋亡的多个下游靶基因表达,对脑缺血后能量代谢障碍的改善以及微循环的建立具有重要意义.HIF-1α既可促进神经元存活,也可诱导神经元迟发性死亡.各种预处理和后处理方法可能通过激活HIF-1α调节神经细胞存亡.
결양유도인자-1(hy poxia-inducible factor-1,HIF-1)시일충중요적전록조절인자,주요통과기활성아기HIF-1α삼여궤체대결양배경적응답.뇌결혈결양시,HIF-1α표체상조,가격활섭급당효해、혈관생장、세포생존화세포조망적다개하유파기인표체,대뇌결혈후능량대사장애적개선이급미순배적건립구유중요의의.HIF-1α기가촉진신경원존활,야가유도신경원지발성사망.각충예처리화후처리방법가능통과격활HIF-1α조절신경세포존망.
Hypoxia-induciole factor-1 (HIF-1) is an important transcription factor.It participates in the body's response to the hypoxic environment mainly through its active subunit HIF-1α.During cerebral ischemia and hypoxia,the expression of HIF-1α is upregulated and may activate the expressions of multiple downstream target genes involving glycolysis,vascular growth,cell survival and apoptosis.It has an important significance for the improvement of energy metabolism and the establishment of microcirculation after cerebral ischemia.HIF-1α can not only promote the neuronal survival,but also mediate delayed neuronal death.A variety of preconditioning and postconditioning methods may regulate the survival and death of neuronal cells by activating HIF-1α.