国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
INTERNATIONAL JOURNAL OF UROLOGY AND NEPHROLOGY
2011年
1期
19-23
,共5页
膀胱肿瘤%基因%MDR
膀胱腫瘤%基因%MDR
방광종류%기인%MDR
Bladder Neoplasms%Genes,MDR
目的 探讨膀胱癌组织中P-糖蛋白(P-gp)和谷胱甘肽S转移酶(GST-π)与CerbB-2、层黏连蛋白受体(LN-R)的表达及其临床意义.方法 回顾性分析膀胱癌的临床与病历资料,应用免疫组织化学方法检测45例膀胱异性细胞癌中P-gp、GST-π和CerbB-2、LN-R基因的表达情况.结果 P-gp、GST-π、CerbB-2和LN-R在膀胱癌中的阳性率分别为42.22%、48.88%、46.66%和37.78%.P-gp、GST-π与CerbB-2在膀胱癌中的表达分级、分期比较差异有统计学意义(p＜0.05);LN-R在转移/未转移病例的表达中比较差异有统计学意义(p＜0.05);P-gp、GST-π与LN-R在2年内复发肿瘤的阳性率高于2年后复发肿瘤,相互间差异具有统计学意义(p＜0.05).结论 P-gp、GST-π、CerbB-2表达与膀胱癌的分期、分级、复发等呈正相关(p＜0.05),随肿瘤分级、分期、浸润性增高,其阳性表达率亦增高,同时P-gp、GST-π可指导膀胱癌化疗药物的选择;LN-R的表达与膀胱癌的转移呈正相关(p＜0.05),可作为判断膀胱癌预后的因素.
目的 探討膀胱癌組織中P-糖蛋白(P-gp)和穀胱甘肽S轉移酶(GST-π)與CerbB-2、層黏連蛋白受體(LN-R)的錶達及其臨床意義.方法 迴顧性分析膀胱癌的臨床與病歷資料,應用免疫組織化學方法檢測45例膀胱異性細胞癌中P-gp、GST-π和CerbB-2、LN-R基因的錶達情況.結果 P-gp、GST-π、CerbB-2和LN-R在膀胱癌中的暘性率分彆為42.22%、48.88%、46.66%和37.78%.P-gp、GST-π與CerbB-2在膀胱癌中的錶達分級、分期比較差異有統計學意義(p＜0.05);LN-R在轉移/未轉移病例的錶達中比較差異有統計學意義(p＜0.05);P-gp、GST-π與LN-R在2年內複髮腫瘤的暘性率高于2年後複髮腫瘤,相互間差異具有統計學意義(p＜0.05).結論 P-gp、GST-π、CerbB-2錶達與膀胱癌的分期、分級、複髮等呈正相關(p＜0.05),隨腫瘤分級、分期、浸潤性增高,其暘性錶達率亦增高,同時P-gp、GST-π可指導膀胱癌化療藥物的選擇;LN-R的錶達與膀胱癌的轉移呈正相關(p＜0.05),可作為判斷膀胱癌預後的因素.
목적 탐토방광암조직중P-당단백(P-gp)화곡광감태S전이매(GST-π)여CerbB-2、층점련단백수체(LN-R)적표체급기림상의의.방법 회고성분석방광암적림상여병력자료,응용면역조직화학방법검측45례방광이성세포암중P-gp、GST-π화CerbB-2、LN-R기인적표체정황.결과 P-gp、GST-π、CerbB-2화LN-R재방광암중적양성솔분별위42.22%、48.88%、46.66%화37.78%.P-gp、GST-π여CerbB-2재방광암중적표체분급、분기비교차이유통계학의의(p＜0.05);LN-R재전이/미전이병례적표체중비교차이유통계학의의(p＜0.05);P-gp、GST-π여LN-R재2년내복발종류적양성솔고우2년후복발종류,상호간차이구유통계학의의(p＜0.05).결론 P-gp、GST-π、CerbB-2표체여방광암적분기、분급、복발등정정상관(p＜0.05),수종류분급、분기、침윤성증고,기양성표체솔역증고,동시P-gp、GST-π가지도방광암화료약물적선택;LN-R적표체여방광암적전이정정상관(p＜0.05),가작위판단방광암예후적인소.
Objectives To investigate bladder cancer P - glycoprotein ( P - gp) and g, lutathione S transferass (GST-π) and CerbB-2, laminin receptor (LN -R) expression and clinical significance. Methods Retrospective analysis of bladder cancer and medical records, were detected by immunohistochemistry in 45 cases of bladder cell carcinoma of the opposite sex in the P - gp, GST - π and CerbB -2, LN - R gene expression. Results P - gp, GST - r, CerbB -2 and LN - R in bladder cancer, the positive rate was 42.22%, 48.88%, 46.66%and 37.78%. P -gp, GST- r and CerbB -2 expression in bladder cancer grade, stage the difference was statistically significant( p<0.05);LN-Rin the transfer / no transfer of cases to compare differences in the expression of statistically significant (p<0.05);P-gp,GST-π and LN - R tumor recurrence within 2 years, the positive rate of tumor recurrence after 2 years, statistically significant differences between each other ( p<0.05). Conclusions P-gp, GST-π, CerbB - 2 expression and bladder cancer stage, grade, recurrence was a positive corelation( p<0.05), with the tumor grade, stage, invasive increased, the positive expression rate also increased,while P - gp, GST - π can guide the choice of chemotherapy of bladder cancer; LN - R expression and metastasis of bladder cancer was positively correlated( p<0.05), could be used as prognostic factors in bladder cancer.
