CAJ | 학술논문

目的研究血脂联素瘦素比值与老年男性代谢综合征的相关性. 方法选择老年男性患者256例,分为代谢综合征组109例和非代谢综合征组(对照组)147例,代谢综合征的诊断采用2004年中国糖尿病学会制定的标准;采用LINCO放射免疫试剂盒测定空腹血脂联素、瘦素水平.结果 (1)老年男性代谢综合征组与对照组瘦素水平分别为(10.3±7.0)μg/L和(6.8±4.9)μg/L,脂联素分别为(7.8±5.6)g/L和(9.5±5.9)g/L,脂联素瘦素比值分别为0.94±0.78和2.15±2.13;(2)脂联素瘦素比值与体质指数、血三酰甘油、血尿酸水平均呈负相关,而与高密度脂蛋白水平显著正相关(P<0.001);(3)随着脂联素瘦素比值升高,代谢综合征发生的可能性减小,当比值在5以上,代谢综合征的患病率降至O(X2=34.891,P<0.001);(4)代谢异常组分数越多.脂联素瘦素比值越低(F=10.876,P<0.001). 结论血脂联素瘦素比值可用于评价老年男性患者代谢紊乱程度,对老年男性代谢综合征的诊断有辅助作用.
목적 연구혈지련소수소비치여노년남성대사종합정적상관성. 방법 선택노년남성환자256례,분위대사종합정조109례화비대사종합정조(대조조)147례,대사종합정적진단채용2004년중국당뇨병학회제정적표준;채용LINCO방사면역시제합측정공복혈지련소、수소수평.결과 (1)노년남성대사종합정조여대조조수소수평분별위(10.3±7.0)μg/L화(6.8±4.9)μg/L,지련소분별위(7.8±5.6)g/L화(9.5±5.9)g/L,지련소수소비치분별위0.94±0.78화2.15±2.13;(2)지련소수소비치여체질지수、혈삼선감유、혈뇨산수평균정부상관,이여고밀도지단백수평현저정상관(P<0.001);(3)수착지련소수소비치승고,대사종합정발생적가능성감소,당비치재5이상,대사종합정적환병솔강지O(X2=34.891,P<0.001);(4)대사이상조분수월다.지련소수소비치월저(F=10.876,P<0.001). 결론 혈지련소수소비치가용우평개노년남성환자대사문란정도,대노년남성대사종합정적진단유보조작용.
Objective To explore the correlation between adiponectin/leptin(A/L) ratio and metabolic syndrome diagnosis in elderly men. Methods A total of 256 elderly men (≥60 years) were enrolled and divided into metabolic syndrome group(n= 109) and non metabolic syndrome group (n= 147). Serum levels of adiponectin and leptin were measured by radioimmunoassay (RIA) and the A/L ratio was calculated. Metabolic syndrome diagnosis is based on the definition provided by China Diabetes Society (CDS) in 2004. Results (1) In metabolic syndrome group versus non metabolic syndrome group, the serum levels of leptin and adiponectin were (10. 3±7.0) vs (6.8±4.9)μg/L and(7.8±5.6)g/L vs (9.5±5.9)g/L, and A/L ratio was 0. 94±0. 78 vs 2.15±2.13 respectively. (2) A/L ratio was positively correlated with high density lipoprotein cholesterol (HDL-C) and negatively correlated with body mass index (BMI), triacylglycerol (TG) and serum uric acid(P< 0. 001). (3) The higher value of A/L ratio, the lower possibility of metabolic syndrome. When the A/L ratio was more than 5, the incidence of metabolic syndrome was decreased to O(X2 =34. 891 ,P< 0.001). (4) The more components of metabolic abnormality, the lower value of A/L ratio(F= 10. 876,P<0. 001). Conclusions The A/L ratio may be useful in evaluating the extent of metabolic disorder and diagnosing metabolic syndrome in elderly men.