中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
6期
10-13
,共4页
陈学波%朱水娣%胡玉纹%吴广宇
陳學波%硃水娣%鬍玉紋%吳廣宇
진학파%주수제%호옥문%오엄우
利钠肽,脑%肾透析%心室功能%左
利鈉肽,腦%腎透析%心室功能%左
리납태,뇌%신투석%심실공능%좌
Natriuretic peptide,brain%Renal dialysis%Ventricularfunction,left
目的 观察老年维持性血液透析(MHD)患者血浆B型利钠肽(BNP)水平与左心功能之间的关系.方法检测50例老年MHD患者(MHD组)和30例健康体检者(健康对照组)的BNP水平,以及彩色多普勒超声心动图测定的左室射血分数(LVEF).分析BNP水平与左心功能之间的关系.结果 MHD组透析前后血浆BNP中位数分别为213.5 ng/L及110.2 ng/L,健康对照组为20.2 ng/L,MHD组的BNP水平透析前后均较健康对照组显著增高(P<0.01),且透析后较透析前显著下降(P<0.01).Spearman等级相关分析结果提示,MHD组的血浆BNP水平与LVEF呈负相关(r=-0.4357,P<0.05).LVEF<50%者20例,透析前后血浆BNP中位数分别为386.5 ng/L和232.0ng/L,LVEF≥50%者30例,透析前后血浆BNP中位数分别为59.7 ng/L和29.1 ng/L,两组比较差异有统计学意义(P<0.01).结论 BNP可反映左心功能的动态变化,可能有助于MHD患者的心血管疾病早期诊断和治疗.
目的 觀察老年維持性血液透析(MHD)患者血漿B型利鈉肽(BNP)水平與左心功能之間的關繫.方法檢測50例老年MHD患者(MHD組)和30例健康體檢者(健康對照組)的BNP水平,以及綵色多普勒超聲心動圖測定的左室射血分數(LVEF).分析BNP水平與左心功能之間的關繫.結果 MHD組透析前後血漿BNP中位數分彆為213.5 ng/L及110.2 ng/L,健康對照組為20.2 ng/L,MHD組的BNP水平透析前後均較健康對照組顯著增高(P<0.01),且透析後較透析前顯著下降(P<0.01).Spearman等級相關分析結果提示,MHD組的血漿BNP水平與LVEF呈負相關(r=-0.4357,P<0.05).LVEF<50%者20例,透析前後血漿BNP中位數分彆為386.5 ng/L和232.0ng/L,LVEF≥50%者30例,透析前後血漿BNP中位數分彆為59.7 ng/L和29.1 ng/L,兩組比較差異有統計學意義(P<0.01).結論 BNP可反映左心功能的動態變化,可能有助于MHD患者的心血管疾病早期診斷和治療.
목적 관찰노년유지성혈액투석(MHD)환자혈장B형리납태(BNP)수평여좌심공능지간적관계.방법검측50례노년MHD환자(MHD조)화30례건강체검자(건강대조조)적BNP수평,이급채색다보륵초성심동도측정적좌실사혈분수(LVEF).분석BNP수평여좌심공능지간적관계.결과 MHD조투석전후혈장BNP중위수분별위213.5 ng/L급110.2 ng/L,건강대조조위20.2 ng/L,MHD조적BNP수평투석전후균교건강대조조현저증고(P<0.01),차투석후교투석전현저하강(P<0.01).Spearman등급상관분석결과제시,MHD조적혈장BNP수평여LVEF정부상관(r=-0.4357,P<0.05).LVEF<50%자20례,투석전후혈장BNP중위수분별위386.5 ng/L화232.0ng/L,LVEF≥50%자30례,투석전후혈장BNP중위수분별위59.7 ng/L화29.1 ng/L,량조비교차이유통계학의의(P<0.01).결론 BNP가반영좌심공능적동태변화,가능유조우MHD환자적심혈관질병조기진단화치료.
Objective To detect the relationship between plasma B-type natriuretic peptide(BNP) and left ventricular function in elderly patients with maintenance hemodialysis (MHD). Method Plasma BNP concentration were measured in 50 MHD patients (MHD group) and 30 healthy controls (control group). Echocardiographic examinations were performed including left ventricular ejection fraction (LVEF). Results The median plasma BNP level in MHD group before and after hemodialysis was 213.5 ng/L and 110.2 ng/L, and obviously higher than that in control group (20.2 ng/L) (P<0.01). Spearman rank correlation showed that plasma BNP level was significantly negatively correlated with LVEF (r=-0.4357, P< 0.05). The median plasma BNP level in the patients with LVEF < 50% before and after hemodialysis was 386.5 ng/L and 232.0 ng/L, significantly higher than that in the patients without left ventricular dysfunction (LVEF≥50%) (59.7 ng/L and 29.1 ng/L)(P<0.01). Conclusions The level of BNP may reflect dynamic change of left ventricular function in MHD patients. It can help to diagnose and treat cardiovascular disease in MHD patients early.
