CAJ | 학술논문

目的探讨如何提高自身抗体(抗SSA/SSB抗体)阴性原发干燥综合征(pSS)患者唇腺活检诊断的刚性率.方法回顾性分析82例抗SSA/SSB抗体阴性疑似pSS患者,行同位素检查腮腺受损情况和进行唇腺活检进行确诊情况.结果 82例患者唇腺活检病理报告阳性51例(62.2%),其中ChisholmⅢ级17例,Ⅳ级34例.51例唇腺活检阳性组中有44例(86.3%)腮腺同位素检查为中度以上受损;31例唇腺活检阴性组中有15例(48.4%)腮腺同位素检查为中度以上受损;2组之间差异有统计学意义(P＜0.01).结论腮腺同位素检查受损在中度以上者,唇腺活检对自身抗体阴性pSS诊断的阳性率较高.
목적 탐토여하제고자신항체(항SSA/SSB항체)음성원발간조종합정(pSS)환자진선활검진단적강성솔.방법 회고성분석82례항SSA/SSB항체음성의사pSS환자,행동위소검사시선수손정황화진행진선활검진행학진정황.결과 82례환자진선활검병리보고양성51례(62.2%),기중ChisholmⅢ급17례,Ⅳ급34례.51례진선활검양성조중유44례(86.3%)시선동위소검사위중도이상수손;31례진선활검음성조중유15례(48.4%)시선동위소검사위중도이상수손;2조지간차이유통계학의의(P＜0.01).결론 시선동위소검사수손재중도이상자,진선활검대자신항체음성pSS진단적양성솔교고.
Objective To improve the diagnosis postive rate of primary Sjogren's syndrome (pSS) by labial salivary gland(LSG) biopsy in patients with negative autoantibodies(SSA/SSB autoantibodies). Methods Eightytwo suspected pSS inpatients with both negative SSA/SSB autoantibodies were analyzed retrospectively. The decreased parotid gland function was tested and the LSG biopsy was performed to confirmed diagnosis. Results There were fifty-one patients(62.2% ) were LSG biopsy positive, including 17 Chisholm Ⅲ and 34 Chisholm Ⅳ in histopathologic grading. And 44(86% ) were found Parotid gland function moderate/severe damaged in the 51 LSG positive patients, moreover 15(48% ) patients were found moderate/severe damaged in 31 LSG negtive patients, A chi-square test was used between the two groups, the difference was significant ( P ＜ 0.01 ), Conclusion LSG biopsy might be sensitive in suspected pSS patients with negtive antoantibodies when the parotid gland function is moderate/severe damaged.