国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2010年
2期
89-92
,共4页
脊髓灰质炎病毒疫苗,口服%酶联免疫吸附测定%抗体,单克隆%D抗原
脊髓灰質炎病毒疫苗,口服%酶聯免疫吸附測定%抗體,單剋隆%D抗原
척수회질염병독역묘,구복%매련면역흡부측정%항체,단극륭%D항원
Poliovirus vaccine,inactivated%Enzyme-linked immunosorbent assay%Antibodies,monoclonal%D antigen
脊髓灰质炎灭活疫苗(inactived poliovirus vaccine ,IPV)的问世使全球范围内消灭脊髓灰质炎成为可能,而且IPV在全球致力于消灭脊髓灰质炎中的作用日益增强.通过IPV D抗原检测可以检测IPV效力,因此IPV D抗原的快速定量检测成为亟待解决的关键问题.目前,最常用的体外检测法是ELISA法,然而,尚无国际公认的标准IPV效力检测法.此文就IPV抗原含量检测方法的研究进展加以综述.
脊髓灰質炎滅活疫苗(inactived poliovirus vaccine ,IPV)的問世使全毬範圍內消滅脊髓灰質炎成為可能,而且IPV在全毬緻力于消滅脊髓灰質炎中的作用日益增彊.通過IPV D抗原檢測可以檢測IPV效力,因此IPV D抗原的快速定量檢測成為亟待解決的關鍵問題.目前,最常用的體外檢測法是ELISA法,然而,尚無國際公認的標準IPV效力檢測法.此文就IPV抗原含量檢測方法的研究進展加以綜述.
척수회질염멸활역묘(inactived poliovirus vaccine ,IPV)적문세사전구범위내소멸척수회질염성위가능,이차IPV재전구치력우소멸척수회질염중적작용일익증강.통과IPV D항원검측가이검측IPV효력,인차IPV D항원적쾌속정량검측성위극대해결적관건문제.목전,최상용적체외검측법시ELISA법,연이,상무국제공인적표준IPV효력검측법.차문취IPV항원함량검측방법적연구진전가이종술.
Development of inactivated poliovirus vaccine (IPV) makes polio eradication on the global scale possible, and IPV plays an increasing role in the global effort to eradicate polio. The potency of IPV is determined by measurement of D antigen in IPV, so the rapid and quantitative assay for D antigen in IPV is an urgent key problem to be resolved. At present, ELISA is the most popular in vitro assay. However, there is no internationally accepted standard IPV potency assay. This paper summarizes research advances in assays for antigen content in IPV.
