CAJ | 학술논문

目的验证抗感染活性骨(anti-infective reconstituted bone xenograft,ARBX)Ⅰ期植骨治疗儿童慢性骨髓炎的疗效.方法自2001年9月对21例慢性骨髓炎患儿进行病灶清除,应用抗感染活性异种骨(anti-infective reconstituted bone xenograft,ARBX)Ⅰ期植骨治疗,其中获得12个月以上随访的儿童慢性骨髓炎患儿共16例.包括血源性慢性骨髓炎8例,原发性慢性骨髓炎3例,创伤性慢性骨髓炎5例.结果 16例中除1例骨髓炎复发,1例骨髓炎合并大段骨缺损在术后发生骨不连外,其余14例感染均获得控制无复发,病变部位均获得确实骨修复.本组感染治愈率(感染控制且无复发)为93.8%,完全治愈率(感染控制既无复发又完成骨修复)为87.5%.结论 ARBX具有高效诱导成骨活性和强效抗感染能力,是Ⅰ期植骨治疗儿童慢性骨髓炎的有效方法.
목적 험증항감염활성골(anti-infective reconstituted bone xenograft,ARBX)Ⅰ기식골치료인동만성골수염적료효.방법 자2001년9월대21례만성골수염환인진행병조청제,응용항감염활성이충골(anti-infective reconstituted bone xenograft,ARBX)Ⅰ기식골치료,기중획득12개월이상수방적인동만성골수염환인공16례.포괄혈원성만성골수염8례,원발성만성골수염3례,창상성만성골수염5례.결과 16례중제1례골수염복발,1례골수염합병대단골결손재술후발생골불련외,기여14례감염균획득공제무복발,병변부위균획득학실골수복.본조감염치유솔(감염공제차무복발)위93.8%,완전치유솔(감염공제기무복발우완성골수복)위87.5%.결론 ARBX구유고효유도성골활성화강효항감염능력,시Ⅰ기식골치료인동만성골수염적유효방법.
Objective To study the effect of anti-infective reconstituted bone xenograft (ARBX) as one-stage grafting on treating various chronic osteomyelitis in children. Methods ARBX was used to treat 16 cases of various chronic osteomyelitis in children as one-stage grafting after debridement since September of 2001. There were 8 cases with haematogenous, 3 with primary and 5 with traumatic chronic osteomyelitis. All patients were followed up for an average period of 39 months (range, 12 to 79 months). Results Except 1 case got recurrent infection and another 1 with nonunion due to large segmental bone defect after operation, other 14 cases were cured with the cure rate was 87. 5% (14/16), which is higher than that of classical therapy. Conclusions ARBX has high osteoinductive activity and enhanced anti-infective capability, which enables it to be used as one-stage grafting to treat various chronic osteomyelitis in children.