中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
6期
612-614
,共3页
重症哮喘%布地奈德混悬液%无创正压通气%雾化吸入
重癥哮喘%佈地奈德混懸液%無創正壓通氣%霧化吸入
중증효천%포지내덕혼현액%무창정압통기%무화흡입
Severe asthma%Budesonide suspension%Noninvasive positive pressure ventilation%Aerosol inhalation
目的 探讨无创正压通气联合雾化吸入布地奈德对重症哮喘患者的临床疗效.方法 将121例重症哮喘患者随机分为两组,均在常规洽疗的基础上进行无创正压通气治疗,布地奈德组同时给予雾化吸入布地奈德混悬液2ml+生理盐水2 ml,2次/d,14 d为1个疗程.对治疗前后两组临床症状改善和血气分析变化情况进行对比性研究,观察疗效.结果 治疗前布地奈德组与对照组pH、PaO2、PaCO2差异均无统计学意义(P均＞0.05),治疗1个疗程后,pH、PaO2高于对照组[(7.43±0.04)、1(7.34±0.02)、t=3.423；(77.4±16.7)、(62.4±16.5)mm Hg、t =3.414],PaCO2低于对照组[(43.4±8.9)、(50.9±9.1)mm Hg、t=5.317],差异均有统计学意义(P均＜0.05).布地奈德组总有效率为96.7％(59/61),对照组为88.3％(53/60),差异有统计学意义(x2=4.218,P＜0.05).结论 临床上无创正压通气联合雾化吸入布地奈德治疗重症哮喘疗效显著,操作简单,值得推广.
目的 探討無創正壓通氣聯閤霧化吸入佈地奈德對重癥哮喘患者的臨床療效.方法 將121例重癥哮喘患者隨機分為兩組,均在常規洽療的基礎上進行無創正壓通氣治療,佈地奈德組同時給予霧化吸入佈地奈德混懸液2ml+生理鹽水2 ml,2次/d,14 d為1箇療程.對治療前後兩組臨床癥狀改善和血氣分析變化情況進行對比性研究,觀察療效.結果 治療前佈地奈德組與對照組pH、PaO2、PaCO2差異均無統計學意義(P均＞0.05),治療1箇療程後,pH、PaO2高于對照組[(7.43±0.04)、1(7.34±0.02)、t=3.423；(77.4±16.7)、(62.4±16.5)mm Hg、t =3.414],PaCO2低于對照組[(43.4±8.9)、(50.9±9.1)mm Hg、t=5.317],差異均有統計學意義(P均＜0.05).佈地奈德組總有效率為96.7％(59/61),對照組為88.3％(53/60),差異有統計學意義(x2=4.218,P＜0.05).結論 臨床上無創正壓通氣聯閤霧化吸入佈地奈德治療重癥哮喘療效顯著,操作簡單,值得推廣.
목적 탐토무창정압통기연합무화흡입포지내덕대중증효천환자적림상료효.방법 장121례중증효천환자수궤분위량조,균재상규흡료적기출상진행무창정압통기치료,포지내덕조동시급여무화흡입포지내덕혼현액2ml+생리염수2 ml,2차/d,14 d위1개료정.대치료전후량조림상증상개선화혈기분석변화정황진행대비성연구,관찰료효.결과 치료전포지내덕조여대조조pH、PaO2、PaCO2차이균무통계학의의(P균＞0.05),치료1개료정후,pH、PaO2고우대조조[(7.43±0.04)、1(7.34±0.02)、t=3.423；(77.4±16.7)、(62.4±16.5)mm Hg、t =3.414],PaCO2저우대조조[(43.4±8.9)、(50.9±9.1)mm Hg、t=5.317],차이균유통계학의의(P균＜0.05).포지내덕조총유효솔위96.7％(59/61),대조조위88.3％(53/60),차이유통계학의의(x2=4.218,P＜0.05).결론 림상상무창정압통기연합무화흡입포지내덕치료중증효천료효현저,조작간단,치득추엄.
Objective To investigate the curative effect of noninvasive positive pressure ventilation combined with aerosol inhalation of budesonide on patients with severe asthma.Methods One hundred and twenty-one patients with severe asthma were randomly assigned to two groups.Both groups were treated with noninvasive positive pressure ventilation based on routine treatment.In addition,patients in the treatment group were given aerosol inhalation of 2 ml budesonide and 2 ml NS,two times each day,14 days for a course.Clinical symptoms improvement and arterial blood pressure changes of two groups before and after treatment were studied to compare the curative effect of the treatments in the two groups.Results There were no significant differences in pH,PaO2 and PaCO2 between the treatment and the control groups(P ＞ 0.05).After one course of treatment,the treatment group had significantly higher levels of pH(7.43 ± 0.04 vs.7.34 ± 0.02,t =3.423,P ＜ 0.05) and PaO2 ( [77.4 ± 16.7 ] mm Hg vs.[ 62.4 ± 16.5 ] mm Hg,t =3.414,P ＜ 0.05 ) and lower levels of PaCO2 ( [43.4 ±8.9] mm Hg vs.[50.9 ± 9.1 ] mm Hg,t =5.317,P ＜ 0.05 ) than the control group.There were significant differences in the total effective rate between the Budesonide group and the control group (96.7％ vs.88.3％,x2 =4.218,P ＜ 0.05 ).Conclusion Noninvasive positive pressure ventilation combined with aerosol inhalation of budesonide is a simple and effective strategy for patients with severe asthma.Thus it may be worthy to be widely used clinically.
